Evidence mapPaperPMID 37047601Full record

ArticleInternational journal of molecular sciences2023

Blood-Brain Barrier Biomarkers before and after Kidney Transplantation.

Leah Hernandez, Liam J Ward, Samsul Arefin, Peter Barany, Lars Wennberg, Magnus Söderberg, Stefania Bruno, Vincenzo Cantaluppi, Peter Stenvinkel, Karolina Kublickiene

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. High-flux hemodialysis with polymethylmethacrylate membranes reduces soluble CD40L, a mediator of cardiovascular disease in uremia.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 2 countries.

Leah HernandezDivision of Renal Medicine, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0002-7443-1626
Liam J WardDivision of Renal Medicine, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0002-3320-1461
Samsul ArefinDivision of Renal Medicine, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0002-8050-9100
Peter BaranyDivision of Renal Medicine, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, 171 77 Stockholm, Sweden.
Lars WennbergDepartment of Transplantation Surgery, Karolinska University Hospital, 141 86 Stockholm, Sweden.
Magnus SöderbergDepartment of Pathology, Clinical Pharmacology and Safety Sciences, R&D AstraZeneca, 431 83 Gothenburg, Sweden.ORCID 0000-0003-0946-5202
Stefania BrunoDepartment of Medical Sciences, University of Torino, 10124 Torino, Italy.ORCID 0000-0002-8879-9536
Vincenzo CantaluppiNephrology and Kidney Transplant Unit, Department of Translational Medicine (DIMET), University of Piemonte Orientale (UPO), "Maggiore della Carita" University Hospital, 28100 Novara, Italy.ORCID 0000-0002-4120-3555
Peter StenvinkelDivision of Renal Medicine, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0002-8785-4820
Karolina KublickieneDivision of Renal Medicine, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0002-4841-6836
Karolinska Institutet · SEAstraZeneca (Sweden) · SEKarolinska University Hospital · SESwedish National Board of Forensic Medicine · SEUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro” · ITUniversity of Turin · IT

Funding

CIMED, Heart and Lung Foundation, Westman and Swedish Medical Research Council; GENDER-NET Plus ERA-NET Initiative Vetenskapsrådet 2018-00932 GOING-FWDItalian Ministry of Education, University and Research (MIUR) program "Departments of Excel-lence 2018-2022", AGING Project-Department of Translational Medicine (DIMET), University of Piemonte Orientale (UPO
6 · The paper itself

Abstract

Kidney transplantation (KT) may improve the neurological status of chronic kidney disease (CKD) patients, reflected by the altered levels of circulating BBB-specific biomarkers. This study compares the levels of neuron specific enolase (NSE), brain-derived neurotrophic factor (BDNF), neurofilament light chain (NfL), and circulating plasma extracellular vesicles (EVs) in kidney-failure patients before KT and at a two-year follow up. Using ELISA, NSE, BDNF, and NfL levels were measured in the plasma of 74 living-donor KT patients. Plasma EVs were isolated with ultracentrifugation, and characterized for concentration/size and surface protein expression using flow cytometry from a subset of 25 patients. Lower NSE levels, and higher BDNF and NfL were observed at the two-year follow-up compared to the baseline (

Indexed as

Kidney TransplantationRenal Insufficiency, ChronicBiomarkersBlood-Brain BarrierBrain-Derived Neurotrophic FactorEndothelial CellsFemaleHumansMaleBiomarkersBrain-Derived Neurotrophic FactorBBBBDNFCKDend-stage kidney failureextracellular vesicleskidney transplantationNfLNSE

Identifiers

PMID37047601
PMCPMC10095132
OpenAlexW4362579423

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.