Evidence map›Paper›PMID 37047673›Full record

ArticleInternational journal of molecular sciences2023

Up-Regulation of microRNA-424 Causes an Imbalance in AKT Phosphorylation and Impairs Enteric Neural Crest Cell Migration in Hirschsprung Disease.

Ze Xu, Yingnan Yan, Beilin Gu, Wei Cai, Yang Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ze XuDepartment of Pediatric Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.
Yingnan YanDepartment of Pediatric Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.
Beilin GuShanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China.
Wei CaiDepartment of Pediatric Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.
Yang WangDepartment of Pediatric Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.ORCID 0000-0003-0842-2446
Shanghai Jiao Tong University · CNShanghai Institute of Nutrition and Health · CN

Funding

National Natural Science Foundation of China 81670469Natural Science Foundation of Shanghai 22ZR1451500Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition 17DZ2272000
6 · The paper itself

Abstract

Insights into the role of microRNAs (miRNAs) in disease pathogenesis have made them attractive therapeutic targets, and numerous miRNAs have been functionally linked to Hirschsprung disease (HSCR), a life-threatening genetic disorder due to defective migration, proliferation, and colonization of enteric neural crest cells (ENCCs) in the gut. Recent studies have demonstrated that miR-424 strongly inhibits migration in a variety of cell types and its potential target

Indexed as

Enteric Nervous SystemHirschsprung DiseaseMicroRNAsAnimalsCell MovementHumansMiceNeural CrestPhosphorylationProto-Oncogene Proteins c-aktTranscription FactorsUp-RegulationMicroRNAsMIRN424 microrna, humanProto-Oncogene Proteins c-aktTranscription FactorsAKT phosphorylationenteric neural crest cellsHirschsprung diseasemiR-424RICTOR

Identifiers

PMID37047673
PMCPMC10094892
OpenAlexW4362560094

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.