Evidence map›Paper›PMID 37048054›Full record

ArticleCells2023

Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget's Disease of Bone.

Emily M Rabjohns, Rishi R Rampersad, Arin Ghosh, Katlyn Hurst, Amanda M Eudy, Jaime M Brozowski, Hyun Ho Lee, Yinshi Ren, Anthony Mirando, Justin Gladman and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Emily M RabjohnsDivision of Rheumatology and Immunology, Duke University Department of Medicine, Durham, NC 27710, USA.ORCID 0000-0002-4171-6836
Rishi R RampersadDivision of Rheumatology and Immunology, Duke University Department of Medicine, Durham, NC 27710, USA.
Arin GhoshCollege of Arts and Sciences, Duke University, Durham, NC 27510, USA.ORCID 0000-0002-3401-9004
Katlyn HurstCollege of Arts and Sciences, Duke University, Durham, NC 27510, USA.
Amanda M EudyDivision of Rheumatology and Immunology, Duke University Department of Medicine, Durham, NC 27710, USA.ORCID 0000-0002-3107-5545
Jaime M BrozowskiDivision of Rheumatology and Immunology, Duke University Department of Medicine, Durham, NC 27710, USA.
Hyun Ho LeeDivision of Rheumatology and Immunology, Duke University Department of Medicine, Durham, NC 27710, USA.
Yinshi RenDepartment of Orthopaedic Surgery, University of Texas Southwestern, Dallas, TX 75390, USA.
Anthony MirandoDepartment of Orthopedics, Duke University, Durham, NC 27710, USA.
Justin GladmanPratt School of Engineering, Duke University, Durham, NC 27710, USA.
Jessica L BowserDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Kathryn BergCentre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.ORCID 0000-0002-5972-4009
Sachin WaniCentre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Stuart H RalstonCentre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.ORCID 0000-0002-2804-7586
Matthew J HiltonDepartment of Orthopedics, Duke University, Durham, NC 27710, USA.ORCID 0000-0003-3165-267X
Teresa K TarrantDivision of Rheumatology and Immunology, Duke University Department of Medicine, Durham, NC 27710, USA.ORCID 0000-0003-4067-5363

Funding

Notch Signaling in Endochondral Bone DevelopmentR01AR071722 · NIAMS · DUKE UNIVERSITY · PI HILTON, MATTHEW J. · 2018 to 2022
$1.8M
G protein-coupled receptor kinase 3 regulation of leukocyte function in inflammatR03AR059286 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TARRANT, TERESA KATHLEEN · 2011 to 2013
$218k
G protein-coupled receptor kinase 3 (GRK3) regulation of receptor signaling in stem cell function and transplantationF31HL128029 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BROZOWSKI, JAIME M · 2015 to 2017
$94k
NHLBI NIH HHS F31 HL128029NIAMS NIH HHS R01 AR071722NIAMS NIH HHS R03 AR059286
6 · The paper itself

Abstract

Paget's Disease of Bone (PDB) is a metabolic bone disease that is characterized by dysregulated osteoclast function leading to focal abnormalities of bone remodeling. It can lead to pain, fracture, and bone deformity. G protein-coupled receptor kinase 3 (GRK3) is an important negative regulator of G protein-coupled receptor (GPCR) signaling. GRK3 is known to regulate GPCR function in osteoblasts and preosteoblasts, but its regulatory function in osteoclasts is not well defined. Here, we report that

Indexed as

Bone Diseases, MetabolicBone ResorptionG-Protein-Coupled Receptor Kinase 3Osteitis DeformansAnimalsHumansLeukocytes, MononuclearMiceOsteoclastsOsteogenesisG-Protein-Coupled Receptor Kinase 3GRK3 protein, humanGRK3 protein, mouseboneG protein-coupled receptorG protein-coupled receptor kinasemetabolic bone diseaseosteoclastPaget’sPaget’s disease of bone

Identifiers

PMID37048054
PMCPMC10093054

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.