Evidence map›Paper›PMID 37048129›Full record

ReviewCells2023

Cracking the Code of Neuronal Cell Fate.

Giovanna Morello, Valentina La Cognata, Maria Guarnaccia, Velia D'Agata, Sebastiano Cavallaro

Abstract readReview
In one paragraph

Review in Cells, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Giovanna MorelloInstitute for Biomedical Research and Innovation, National Research Council (CNR-IRIB), 95126 Catania, Italy.
Valentina La CognataInstitute for Biomedical Research and Innovation, National Research Council (CNR-IRIB), 95126 Catania, Italy.ORCID 0000-0003-4066-0655
Maria GuarnacciaInstitute for Biomedical Research and Innovation, National Research Council (CNR-IRIB), 95126 Catania, Italy.
Velia D'AgataSection of Human Anatomy and Histology, Department of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania, Italy.ORCID 0000-0003-1114-8265
Sebastiano CavallaroInstitute for Biomedical Research and Innovation, National Research Council (CNR-IRIB), 95126 Catania, Italy.ORCID 0000-0001-7590-1792

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcriptional regulation is fundamental to most biological processes and reverse-engineering programs can be used to decipher the underlying programs. In this review, we describe how genomics is offering a systems biology-based perspective of the intricate and temporally coordinated transcriptional programs that control neuronal apoptosis and survival. In addition to providing a new standpoint in human pathology focused on the regulatory program, cracking the code of neuronal cell fate may offer innovative therapeutic approaches focused on downstream targets and regulatory networks. Similar to computers, where faults often arise from a software bug, neuronal fate may critically depend on its transcription program. Thus, cracking the code of neuronal life or death may help finding a patch for neurodegeneration and cancer.

Indexed as

Gene Expression RegulationNeuronsApoptosisCell DeathCell DifferentiationHumansapoptosisdrug repurposingdrug targetsfunctional enrichmentneurological diseaseneurotrophic factorsregulatory networksurvivaltranscriptional analysis

Identifiers

PMID37048129
PMCPMC10093029

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.