Evidence map›Paper›PMID 37048495›Full record

ArticleAnimals : an open access journal from MDPI2023

Characterization of Growth Secondary Hair in Min Pig Activated by Follicle Stem Cell Stimulated by Wnt and BMP Signaling Pathway.

Xinmiao He, Ziliang Qin, Ran Teng, Ming Tian, Wentao Wang, Yanzhong Feng, Heshu Chen, Haijuan He, Haifeng Zhang, Di Liu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Animals : an open access journal from MDPI, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xinmiao HeKey Laboratory of Combining Farming and Animal Husbandry, Ministry of Agriculture and Rural Affairs, Animal Husbandry Research Institute, Heilongjiang Academy of Agricultural Sciences, No. 368 Xuefu Road, Harbin 150086, China.
Ziliang QinCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Ran TengCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.
Ming TianKey Laboratory of Combining Farming and Animal Husbandry, Ministry of Agriculture and Rural Affairs, Animal Husbandry Research Institute, Heilongjiang Academy of Agricultural Sciences, No. 368 Xuefu Road, Harbin 150086, China.ORCID 0000-0001-8046-0944
Wentao WangKey Laboratory of Combining Farming and Animal Husbandry, Ministry of Agriculture and Rural Affairs, Animal Husbandry Research Institute, Heilongjiang Academy of Agricultural Sciences, No. 368 Xuefu Road, Harbin 150086, China.
Yanzhong FengKey Laboratory of Combining Farming and Animal Husbandry, Ministry of Agriculture and Rural Affairs, Animal Husbandry Research Institute, Heilongjiang Academy of Agricultural Sciences, No. 368 Xuefu Road, Harbin 150086, China.
Heshu ChenKey Laboratory of Combining Farming and Animal Husbandry, Ministry of Agriculture and Rural Affairs, Animal Husbandry Research Institute, Heilongjiang Academy of Agricultural Sciences, No. 368 Xuefu Road, Harbin 150086, China.
Haijuan HeKey Laboratory of Combining Farming and Animal Husbandry, Ministry of Agriculture and Rural Affairs, Animal Husbandry Research Institute, Heilongjiang Academy of Agricultural Sciences, No. 368 Xuefu Road, Harbin 150086, China.
Haifeng ZhangKey Laboratory of Combining Farming and Animal Husbandry, Ministry of Agriculture and Rural Affairs, Animal Husbandry Research Institute, Heilongjiang Academy of Agricultural Sciences, No. 368 Xuefu Road, Harbin 150086, China.
Di LiuKey Laboratory of Combining Farming and Animal Husbandry, Ministry of Agriculture and Rural Affairs, Animal Husbandry Research Institute, Heilongjiang Academy of Agricultural Sciences, No. 368 Xuefu Road, Harbin 150086, China.
Xinpeng JiangCollege of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China.ORCID 0000-0003-1128-2157
Ministry of Agriculture and Rural Affairs · CNNortheast Agricultural University · CN

Funding

Heilongjiang Province Science Fund for Excellent Young Scholars YQ2020C008National Natural Science Foundation of China 31902169Young Talents" Project of Northeast Agricultural University 18QC39
6 · The paper itself

Abstract

In China, the national-level protected pig, the Min pig, is characterized by the development of secondary hairs and hair follicles in winter. Factors that dominate the genotype in the growth of secondary hairs are not clear through the concrete cell signaling pathways. This study compared hair phenotypes based on morphological structure, transcriptomics, and potential targeting molecules in the breeds of Min, Berkshire, and Yorkshire pigs. The results indicated that Min pigs have specific characteristics for the growth of secondary hairs compared with the Berkshire and Yorkshire pigs. The transcriptome analyses and quantitative reverse transcription-polymerase chain reaction results revealed that secondary hair growth was activated by follicle stem cells. The specific inhibitors of Wnt and BMP were studied using respective signals. The density of follicles, activity of follicle stem cells, and relative gene expression results have shown that Wnt and BMP stimulate the activity of follicle stem cells, and the Wnt signaling molecule has a significantly better effect than the BMP signaling molecule on stem cells. Wnt and BMP can promote the growth of local secondary hair and gene expression. Therefore, this study was conducted to verify the development mechanisms of secondary hairs, which have potential applications in laboratory animals and comparative medicine.

Indexed as

BMPfollicle stem cellMin pigWnt

Identifiers

PMID37048495
PMCPMC10093081
OpenAlexW4362559694

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.