Evidence map›Paper›PMID 37051051›Full record

ArticleCurrent stem cell reports2022

Applying the Cytocentric Principles to Regenerative Medicine for Reproducibility.

Alicia D Henn, Kunal Mitra, Joshua Hunsberger, Xiuzhi Susan Sun, Mark Nardone, Ramon Montero, Sita Somara, Gary Green, Alan Blanchard, Yu Shrike Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current stem cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cytocentric measurement for regenerative medicine.Frontiers in medical technology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alicia D HennBioSpherix, Ltd, 25 Union St, Parish, NY 13131, USA.ORCID 0000-0001-8320-2369
Kunal MitraBiomedical Engineering, Florida Institute of Technology, Melbourne, FL, USA.
Joshua HunsbergerRegenMed Development Organization, Winston-Salem, NC, USA.
Xiuzhi Susan SunKansas State University, Manhattan, KS, USA.
Mark NardoneBio-Trac, Germantown, MD, USA.
Ramon MonteroAkron Biotech, Boca Raton, FL, USA.
Sita SomaraRTI International, Durham, NC, USA.
Gary GreenRegenMed Development Organization, Winston-Salem, NC, USA.
Alan BlanchardThrive Bioscience, Beverly, MA, USA.
Yu Shrike ZhangDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, USA.
Carl G SimonBiosystems and Biomaterials Division, National Institute of Standards and Technology, Gaithersburg, MD, USA.
Randy YerdenBioSpherix, Ltd, 25 Union St, Parish, NY 13131, USA.

Funding

Intramural NIST DOC 9999-NIST
6 · The paper itself

Abstract

Purpose of Review: Cell and tissue products do not just reflect their present conditions; they are the culmination of all they have encountered over time. Currently, routine cell culture practices subject cell and tissue products to highly variable and non-physiologic conditions. This article defines five cytocentric principles that place the conditions for cells at the core of what we do for better reproducibility in Regenerative Medicine. Recent Findings: There is a rising awareness of the cell environment as a neglected, but critical variable. Recent publications have called for controlling culture conditions for better, more reproducible cell products. Summary: Every industry has basic quality principles for reproducibility. Cytocentric principles focus on the fundamental needs of cells: protection from contamination, physiologic simulation, and full-time conditions for cultures that are optimal, individualized, and dynamic. Here, we outline the physiologic needs, the technologies, the education, and the regulatory support for the cytocentric principles in regenerative medicine.

Indexed as

Cell cultureCytocentricOrganoidsRegenerative medicineStem cellsTissue engineering

Identifiers

PMID37051051
PMCPMC10088063

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.