Evidence map›Paper›PMID 37052684›Full record

ArticleCellular and molecular life sciences : CMLS2023

Effects of short-term endurance and strength exercise in the molecular regulation of skeletal muscle in hyperinsulinemic and hyperglycemic Slc2a4

Vitor Rosetto Muñoz, José Diego Botezelli, Rafael Calais Gaspar, Alisson L da Rocha, Renan Fudoli Lins Vieira, Barbara Moreira Crisol, Renata Rosseto Braga, Matheus Brandemarte Severino, Susana Castelo Branco Ramos Nakandakari, Gabriel Calheiros Antunes and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Mitochondrial Maintenance in Skeletal Muscle.Cold Spring Harbor perspectives in biology · 2025
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 1 country.

Vitor Rosetto Muñoz *Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil. vitor.munoz93@gmail.com.ORCID http://orcid.org/0000-0003-4280-6558
José Diego Botezelli *Laboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Rafael Calais GasparLaboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Alisson L da RochaLaboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Renan Fudoli Lins VieiraLaboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Barbara Moreira CrisolLaboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Renata Rosseto BragaLaboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Matheus Brandemarte SeverinoMultidisciplinary Laboratory of Food and Health (LabMAS), School of Applied Sciences (FCA), University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Susana Castelo Branco Ramos NakandakariLaboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira,, São Paulo, Brazil.
Gabriel Calheiros AntunesLaboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Sérgio Q BrunettoBiomedical Engineering Center, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Celso D RamosBiomedical Engineering Center, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Lício Augusto VellosoOCRC - Obesity and Comorbidities Research Center, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Fernando Moreira SimabucoMultidisciplinary Laboratory of Food and Health (LabMAS), School of Applied Sciences (FCA), University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Leandro Pereira de MouraLaboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Adelino Sanchez Ramos da SilvaPostgraduate Program in Rehabilitation and Functional Performance, Ribeirão, Preto Medical School, University of São Paulo (USP), School of Physical Education and Sport of Ribeirão Preto , Ribeirão Preto, São Paulo, Brazil.
Eduardo Rochete RopelleLaboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil.
Dennys Esper CintraLaboratory of Nutritional Genomics, University of Campinas (UNICAMP), Limeira,, São Paulo, Brazil.
José Rodrigo PauliLaboratory of Molecular Biology of Exercise, University of Campinas (UNICAMP), Limeira, São Paulo, Brazil. rodrigopaulifca@gmail.com.
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade de São Paulo · BR

Funding

CAPES 001CNPQ 140285/2016-4CNPQ 303571/2018-7CNPQ 306535/2017-3CNPQ 442542/2014-3Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/26000- 2Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/18488-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/20872-6Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/11820-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/13443-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/08692-5
6 · The paper itself

Abstract

objectiveIntriguingly, hyperinsulinemia, and hyperglycemia can predispose insulin resistance, obesity, and type 2 diabetes, leading to metabolic disturbances. Conversely, physical exercise stimulates skeletal muscle glucose uptake, improving whole-body glucose homeostasis. Therefore, we investigated the impact of short-term physical activity in a mouse model (Slc2a4

methodsSlc2a4

resultsWhen Slc2a4

conclusionsBoth short-term exercise protocols were efficient in whole-body glucose homeostasis and insulin resistance. While endurance exercise plays an important role in transcriptome and mitochondrial activity, strength exercise mostly affects post-translational mechanisms and protein synthesis in skeletal muscle. Thus, the performance of both types of physical exercise proved to be a very effective way to mitigate the impacts of hyperglycemia and hyperinsulinemia in the Slc2a4

Indexed as

Diabetes Mellitus, Type 2HyperglycemiaInsulin ResistanceAnimalsGlucoseGlucose Transporter Type 4MiceMuscle, SkeletalGlucoseGlucose Transporter Type 4Slc2a4 protein, mouseHyperinsulinemiaMitochondrial adaptationsPhysical exerciseSkeletal muscle

Identifiers

PMID37052684
PMCPMC11072257
OpenAlexW4365443216

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.