Evidence map›Paper›PMID 37055181›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

VGLUT3 Deletion Rescues Motor Deficits and Neuronal Loss in the zQ175 Mouse Model of Huntington's Disease.

Karim S Ibrahim, Salah El Mestikawy, Khaled S Abd-Elrahman, Stephen S G Ferguson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 4 countries.

Karim S IbrahimUniversity of Ottawa Brain and Mind Research Institute.
Salah El MestikawyNeuroscience Paris Seine, Institut de Biologie Paris Seine, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, Sorbonne Université, 75006, France Paris.ORCID 0000-0002-6253-0002
Khaled S Abd-ElrahmanUniversity of Ottawa Brain and Mind Research Institute.ORCID 0000-0001-9724-1975
Stephen S G FergusonUniversity of Ottawa Brain and Mind Research Institute sferguso@uottawa.ca.ORCID 0000-0002-0887-7312
University of Ottawa · CADouglas Mental Health University Institute · CA

Funding

CIHR PJT-148656CIHR PJT-165967CIHR PJT-178060
6 · The paper itself

Abstract

Huntington's disease (HD) is an autosomal-dominant neurodegenerative disease characterized by progressive motor and cognitive impairments, with no disease-modifying therapies yet available. HD pathophysiology involves evident impairment in glutamatergic neurotransmission leading to severe striatal neurodegeneration. The vesicular glutamate transporter-3 (VGLUT3) regulates the striatal network that is centrally affected by HD. Nevertheless, current evidence on the role of VGLUT3 in HD pathophysiology is lacking. Here, we crossed mice lacking

Indexed as

Huntington DiseaseNeurodegenerative DiseasesAnimalsCorpus StriatumDisease Models, AnimalFemaleHuntingtin ProteinMaleMiceMice, TransgenicNeostriatumVesicular Glutamate Transport ProteinsHuntingtin ProteinVesicular Glutamate Transport ProteinsglutamateHuntington's diseasemotor dysfunctionneurodegeneration, microglia

Identifiers

PMID37055181
PMCPMC10255028
OpenAlexW4365445823

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.