Evidence map›Paper›PMID 37055514›Full record

ArticleScientific reports2023

Effects of bariatric surgery and dietary intervention on insulin resistance and appetite hormones over a 3 year period.

Malgorzata M Brzozowska, Michelle Isaacs, Dana Bliuc, Paul A Baldock, John A Eisman, Chris P White, Jerry R Greenfield, Jacqueline R Center

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 4 pooled it
9.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Review
  7. Observational
  8. Article
  9. Article
  10. Observational
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Sex-differential testosterone response to long-term weight loss.International journal of obesity (2005) · 2024
    Observational
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Malgorzata M BrzozowskaEndocrinology, The Sutherland Hospital, Caringbah, Australia. Malgorzata.Brzozowska@health.nsw.gov.au.ORCID 0000-0003-0700-7750
Michelle IsaacsFaculty of Medicine, UNSW Sydney, Sydney, Australia.
Dana BliucFaculty of Medicine, UNSW Sydney, Sydney, Australia.ORCID 0000-0001-9682-2313
Paul A BaldockFaculty of Medicine, UNSW Sydney, Sydney, Australia.
John A EismanFaculty of Medicine, UNSW Sydney, Sydney, Australia.ORCID 0000-0002-7162-7471
Chris P WhiteFaculty of Medicine, UNSW Sydney, Sydney, Australia.ORCID 0000-0002-7732-2206
Jerry R GreenfieldFaculty of Medicine, UNSW Sydney, Sydney, Australia.ORCID 0000-0002-0866-0973
Jacqueline R CenterFaculty of Medicine, UNSW Sydney, Sydney, Australia.ORCID 0000-0002-5278-4527
Garvan Institute of Medical Research · AUUNSW Sydney · AUNew South Wales Department of Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To examine an impact of three types of bariatric surgery compared with dietary intervention (DIET), on concurrent changes in Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and appetite hormones over 3 years. Fifty-five adults were studied during phase of weight loss (0-12 months) and during weight stability (12-36 months) post intervention. Measurements of HOMA-IR, fasting and postprandial PYY and GLP1, adiponectin, CRP, RBP4, FGF21 hormones and dual-Xray absorptiometry were performed throughout the study. All surgical groups achieved significant reductions in HOMA-IR with greatest difference between Roux-en-Y gastric bypass and DIET (- 3.7; 95% CI - 5.4, - 2.1; p = 0.001) at 12-36 months. Initial (0-12 months) HOMA-IR values were no different to DIET after adjustment for the lost weight. During 12-36 months, after controlling for treatment procedure and weight, for every twofold increase in postprandial PYY and adiponectin, HOMA-IR decreased by 0.91 (95% CI - 1.71, - 0.11; p = 0.030) and by 0.59 (95% CI - 1.10, - 0.10; p = 0.023) respectively. Initial, non-sustained changes in RBP4 and FGF21 were not associated with HOMA-IR values. While initial rapid weight loss reduces insulin resistance, the enhanced secretions of PYY and adiponectin may contribute to weight-independent improvements in HOMA-IR during weight stability.Clinical trial registration: Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12613000188730.

Indexed as

Bariatric SurgeryGastric BypassInsulin ResistanceAdiponectinAdultAppetiteAustraliaBlood GlucoseHumansInsulinRetinol-Binding Proteins, PlasmaWeight LossAdiponectinBlood GlucoseInsulinRBP4 protein, humanRetinol-Binding Proteins, Plasma

Identifiers

PMID37055514
PMCPMC10102182
OpenAlexW4365452242

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.