Evidence map›Paper›PMID 37055945›Full record

ArticleCell cycle (Georgetown, Tex.)2023

Hesperidin mitigates oxidative stress-induced ferroptosis in nucleus pulposus cells via Nrf2/NF-κB axis to protect intervertebral disc from degeneration.

Jian Zhu, Ruping Sun, Chen Yan, Kaiqiang Sun, Lu Gao, Bing Zheng, Jiangang Shi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Hesperetin Induces Ferroptosis-Like Response inJournal of microbiology and biotechnology · 2026
    Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jian ZhuDepartment of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.
Ruping SunSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Chen YanDepartment of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.
Kaiqiang SunDepartment of Orthopaedic Surgery, Naval Medical Center, Naval Medical University, Shanghai, China.
Lu GaoDepartment of Department of Physiology, Naval Medical University, Shanghai, China.
Bing ZhengDepartment of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.
Jiangang ShiDepartment of Orthopedics, Changzheng Hospital, Naval Medical University, Shanghai, China.
Shanghai Changzheng Hospital · CNSecond Military Medical University · CNUniversity of Shanghai for Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intervertebral disc degeneration (IVDD), a widely known contributor to low back pain (LBP), has been proved to be a global health challenging conundrum. Hesperidin (hesperetin-7-O-rutinoside, HRD) is a flavanone glycoside that belongs to the subgroup of citrus flavonoids with therapeutic effect on various diseases due to its anti-inflammatory, antioxidant properties. However, the effect of HRD on IVDD remains elusive. The human nucleus pulposus tissues were harvested for isolating human nucleus pulposus (HNP) cells to verify the expression of Nrf2. The biological effect of HRD on HNP cells were assessed in vitro, and the in vivo therapeutic effects of HRD were assessed in mice. Firstly, we found that the expression of Nrf2 was decreased with the progression of degeneration in degenerated human nucleus pulposus tissue. Subsequently, we confirmed that HRD could mitigate oxidative stress-induced ferroptosis in nucleus pulposus cells via enhancing the expression of Nrf2 axis and suppressing the NF-κB pathway to protect intervertebral disc from degeneration in vitro. Finally, the therapeutic effects of HRD were confirmed in vivo. The current study proved for the first time that HRD may protect HNP cells from degeneration by suppressing ferroptosis in an oxidative stress-dependent via enhancing the expression of Nrf2 and suppressing the NF-κB pathway. The evidence will provide a possible basis for future targeted treatment for IVDD.

Indexed as

FerroptosisHesperidinIntervertebral DiscIntervertebral Disc DegenerationNucleus PulposusAnimalsHumansMiceNF-E2-Related Factor 2NF-kappa BOxidative StressSignal TransductionHesperidinNF-E2-Related Factor 2NF-kappa BferroptosisHesperidinintervertebral disc degeneration

Identifiers

PMID37055945
PMCPMC10193898
OpenAlexW4365479036

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.