Evidence map›Paper›PMID 37056151›Full record

ArticleNeural regeneration research2023

Neuroprotective effect of mesenchymal stem cell-derived extracellular vesicles on optic nerve injury in chronic ocular hypertension.

Fei Yu, Yao Wang, Chang-Quan Huang, Si-Jie Lin, Ru-Xin Gao, Ren-Yi Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  18. Mesenchymal stem cells for repairing glaucomatous optic nerve.International journal of ophthalmology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fei YuDepartment of Glaucoma, Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, School of Medicine, Xiamen University; Fujian Provincial Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian Province, China.
Yao WangShaanxi Provincial Key Lab of Ophthalmology, Shaanxi Clinical Study Center for Ocular Disease, Shaanxi Institute of Ophthalmology, First Affiliated Hospital, Medical School, Northwest University, Xi'an, Shaanxi Province, China.
Chang-Quan HuangDepartment of Glaucoma, Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, School of Medicine, Xiamen University; Fujian Provincial Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian Province, China.
Si-Jie LinEye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Xiamen, Fujian Province, China.
Ru-Xin GaoDepartment of Glaucoma, Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, School of Medicine, Xiamen University; Fujian Provincial Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian Province, China.
Ren-Yi WuDepartment of Glaucoma, Eye Institute and Affiliated Xiamen Eye Center of Xiamen University, School of Medicine, Xiamen University; Fujian Provincial Key Laboratory of Corneal & Ocular Surface Diseases, Xiamen, Fujian Province; Department of Glaucoma, Shanghai Peace Eye Hospital, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesenchymal stem cells have neuroprotective effects that limit damage to the retina and photoreceptors, and which may be mediated by extracellular vesicles (or exosomes) released by mesenchymal stem cells. To investigate the neuroprotective effect of extracellular vesicles derived from umbilical cord mesenchymal stem cells on glaucoma, we established rat models of chronic ocular hypertension by injecting conjunctival fibroblasts into the anterior chamber to mimic optic nerve injury caused by glaucoma. One week after injury, extracellular vesicles derived from umbilical cord-derived mesenchymal stem cells were injected into the vitreous cavity. We found that extracellular vesicles derived from mesenchymal stem cells substantially reduced retinal damage, increased the number of retinal ganglion cells, and inhibited the activation of caspase-3. These findings suggest that mesenchymal stem cell-derived extracellular vesicles can help alleviate optic nerve injury caused by chronic ocular hypertension, and this effect is achieved by inhibiting cell apoptosis.

Indexed as

animal modelapoptosischronic glaucomachronic ocular hypertensionextracellular vesiclesmesenchymal stem cellsneuroprotectionratretinal ganglion cellsumbilical cord

Identifiers

PMID37056151
PMCPMC10328261

What Socratic holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.