Evidence map›Paper›PMID 37058079›Full record

ReviewSmall (Weinheim an der Bergstrasse, Germany)2024

Nanotechnology Approaches for Prevention and Treatment of Chemotherapy-Induced Neurotoxicity, Neuropathy, and Cardiomyopathy in Breast and Ovarian Cancer Survivors.

Sarah Nevins, Callan D McLoughlin, Alfredo Oliveros, Joshua B Stein, Mohammad Abdur Rashid, Yannan Hou, Mi-Hyeon Jang, Ki-Bum Lee

Open access · hybridAbstract readReview
In one paragraph

Review in Small (Weinheim an der Bergstrasse, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Current Research in Drug-Free Cancer Therapies.Bioengineering (Basel, Switzerland) · 2025
    Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sarah NevinsDepartment of Chemistry and Chemical Biology, Rutgers University, the State University of New Jersey, 123 Bevier Road, Piscataway, NJ, 08854, USA.
Callan D McLoughlinDepartment of Chemistry and Chemical Biology, Rutgers University, the State University of New Jersey, 123 Bevier Road, Piscataway, NJ, 08854, USA.
Alfredo OliverosDepartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, the State University of New Jersey, 661 Hoes Ln W, Piscataway, NJ, 08854, USA.
Joshua B SteinDepartment of Chemistry and Chemical Biology, Rutgers University, the State University of New Jersey, 123 Bevier Road, Piscataway, NJ, 08854, USA.
Mohammad Abdur RashidDepartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, the State University of New Jersey, 661 Hoes Ln W, Piscataway, NJ, 08854, USA.
Yannan HouDepartment of Chemistry and Chemical Biology, Rutgers University, the State University of New Jersey, 123 Bevier Road, Piscataway, NJ, 08854, USA.
Mi-Hyeon JangDepartment of Neurosurgery, Robert Wood Johnson Medical School, Rutgers University, the State University of New Jersey, 661 Hoes Ln W, Piscataway, NJ, 08854, USA.
Ki-Bum LeeDepartment of Chemistry and Chemical Biology, Rutgers University, the State University of New Jersey, 123 Bevier Road, Piscataway, NJ, 08854, USA.ORCID 0000-0002-8164-0047
Rutgers, The State University of New Jersey · US

Funding

X-RAY STRUCTURE OF RIFM PROTEIN FROM THE BIOSYNTHESIS PATHWAY OF THE ANSAMYCIN AP41RR012408 · NCRR · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI SWEET, ROBERT M · 1998 to 2011
$32.2M
Rutgers Optimizes Innovation (ROI) ProgramU01HL150852 · NHLBI · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI LIBUTTI, STEVEN K., PANETTIERI, REYNOLD ALEXANDER · 2019 to 2022
$4.4M
Rutgers Biotechnology Training ProgramT32GM135141 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI ANN M. STOCK, Martin L Yarmush · 2020 to 2026
$3.5M
PQ#12; Targeting Nampt-mediated NAD+ metabolism in chemobrainR01CA242158 · NCI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI JANG, MI-HYEON · 2019 to 2023
$2.8M
Machine learning-enabled Comparative Transcriptomic Profiling to Validate NanoScript-induced Inner Ear Hair CellsR01DC016612 · NIDCD · RUTGERS, THE STATE UNIV OF N.J. · PI KWAN, KELVIN Y., LEE, KIBUM · 2018 to 2022
$2.8M
Role of BubR1 as a juvenile protective factor in hippocampal agingR01AG058560 · NIA · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI JANG, MI-HYEON · 2018 to 2022
$2.3M
UCSD Leading the Advancement of Underrepresented Neuroscientists for Change (LAUNCH) Faculty Development ProgramR25NS117367 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Victoria B Risbrough, Joann Trejo · 2020 to 2026
$1.6M
Nanoparticle-based synthetic transcription factor to induce stem cell myogenesisR21AR071101 · NIAMS · RUTGERS, THE STATE UNIV OF N.J. · PI LEE, KIBUM · 2017 to 2018
$371k
Alzheimer's Association AARG-NTF-21-847862NCI NIH HHS R01 CA242158NCRR NIH HHS P41 RR012408New Jersey Commission on Spinal Cord Research CSCR16ERG019New Jersey Commission on Spinal Cord Research CSCR17IRG010NHLBI NIH HHS NHLBINHLBI NIH HHS U01 HL150852NHLBI NIH HHS U01HL150852NIAMS NIH HHS R21 AR071101NIA NIH HHS R01 AG058560NIDCD NIH HHS R01 DC016612NIGMS NIH HHS T32 GM135141NIH HHS R01CA242158NIH R01 1R01DC016612NIH R01 3R01DC016612-01S1NIH R01 5R01DC016612-02S1NIH R21 R21AR071101NIH T32 Biotechnology Training Program GM135141NINDS NIH HHS R25 NS117367N.J. Commission on Cancer Research COCR23PPR007NSF CBET-1803517
6 · The paper itself

Abstract

Nanotechnology has emerged as a promising approach for the targeted delivery of therapeutic agents while improving their efficacy and safety. As a result, nanomaterial development for the selective targeting of cancers, with the possibility of treating off-target, detrimental sequelae caused by chemotherapy, is an important area of research. Breast and ovarian cancer are among the most common cancer types in women, and chemotherapy is an essential treatment modality for these diseases. However, chemotherapy-induced neurotoxicity, neuropathy, and cardiomyopathy are common side effects that can affect breast and ovarian cancer survivors quality of life. Therefore, there is an urgent need to develop effective prevention and treatment strategies for these adverse effects. Nanoparticles (NPs) have extreme potential for enhancing therapeutic efficacy but require continued research to elucidate beneficial interventions for women cancer survivors. In short, nanotechnology-based approaches have emerged as promising strategies for preventing and treating chemotherapy-induced neurotoxicity, neuropathy, and cardiomyopathy. NP-based drug delivery systems and therapeutics have shown potential for reducing the side effects of chemotherapeutics while improving drug efficacy. In this article, the latest nanotechnology approaches and their potential for the prevention and treatment of chemotherapy-induced neurotoxicity, neuropathy, and cardiomyopathy in breast and ovarian cancer survivors are discussed.

Indexed as

Antineoplastic AgentsBreast NeoplasmsCardiomyopathiesNanotechnologyOvarian NeoplasmsCancer SurvivorsFemaleHumansNanoparticlesNeurotoxicity SyndromesAntineoplastic Agentscardiomyopathynanotechnology and nanomedicineneuropathyneurotoxicityovarian and breast cancer

Identifiers

PMID37058079
PMCPMC10576016
OpenAlexW4365483736

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.