Evidence map›Paper›PMID 37064000›Full record

ArticleBone reports2023

Lead induced differences in bone properties in osteocalcin +/+ and -/- female mice.

G Yildirim, W C Budell, O Berezovska, S Yagerman, S S Maliath, P Mastrokostas, S Tommasini, T L Dowd

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

G YildirimDepartment of Chemistry, Brooklyn College of the City University of New York, Brooklyn, NY, USA.
W C BudellDepartment of Chemistry, Brooklyn College of the City University of New York, Brooklyn, NY, USA.
O BerezovskaDepartment of Chemistry, Brooklyn College of the City University of New York, Brooklyn, NY, USA.
S YagermanSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA.
S S MaliathDepartment of Chemistry, Brooklyn College of the City University of New York, Brooklyn, NY, USA.
P MastrokostasDepartment of Chemistry, Brooklyn College of the City University of New York, Brooklyn, NY, USA.
S TommasiniDepartment of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, USA.
T L DowdDepartment of Chemistry, Brooklyn College of the City University of New York, Brooklyn, NY, USA.
Brooklyn College · USCity University of New York · USCornell University · USThe Graduate Center, CUNY · USYale University · US

Funding

Effect of Pb2+ Toxicity at the Molecular LevelR01ES009032 · NIEHS · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI DOWD, TERRY LYNNE · 2005 to 2009
$1.0M
NOT STATEDR29ES009032 · NIEHS · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI DOWD, TERRY L · 1997 to 2001
$190k
NIEHS NIH HHS R01 ES009032NIEHS NIH HHS R29 ES009032
6 · The paper itself

Abstract

Lead (Pb) toxicity is a major health problem and bone is the major reservoir. Lead is detrimental to bone, affects bone remodeling and is associated with elderly fractures. Osteocalcin (OC) affects bone remodeling, improves fracture resistance and decreases with age and in some diseases. The effect of lead in osteocalcin depleted bone is unknown and of interest. We compared bone mineral properties of control and Pb exposed (from 2 to 6 months) femora from female adult C57BL6 OC+/+ and OC-/- mice using Fourier Transform Infrared Imaging (FTIRI), Micro-computed tomography (uCT), bone biomechanical measurements and serum turnover markers (P1NP, CTX). Lead significantly increased turnover in OC+/+ and in OC-/- bones producing increased total volume, area and marrow area/total area with decreased BV/TV compared to controls. The increased turnover decreased mineral/matrix vs. Oc+/+ and increased mineral/matrix and crystallinity vs. OC-/-. PbOC-/- had increased bone formation, cross-sectional area (Imin) and decreased collagen maturity compared OC-/- and PbOC+/+. Imbalanced turnover in PbOC-/- confirmed the role of osteocalcin as a coupler of formation and resorption. Bone strength and stiffness were reduced in OC-/- and PbOC-/- due to reduced material properties vs. OC+/+ and PbOC+/+ respectively. The PbOC-/- bones had increased area to compensate for weaker material properties but were not proportionally stronger for increased size. However, at low lead levels osteocalcin plays the major role in bone strength suggesting increased fracture risk in low Pb

Indexed as

BiomechanicsFTIRIMiceMicroCTOsteocalcin knock-out mousePb2+ toxicity

Identifiers

PMID37064000
PMCPMC10090701
OpenAlexW4327748021

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.