Evidence map›Paper›PMID 37064875›Full record

ArticleTheranostics2023

The lysophosphatidic acid-regulated signal transduction network in ovarian cancer cells and its role in actomyosin dynamics, cell migration and entosis.

Kaire Ojasalu, Sonja Lieber, Anna M Sokol, Andrea Nist, Thorsten Stiewe, Imke Bullwinkel, Florian Finkernagel, Silke Reinartz, Sabine Müller-Brüsselbach, Robert Grosse and 2 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

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  10. High Co-Expression ofBiomedicines · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Kaire OjasaluDepartment of Translational Oncology, Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany.
Sonja LieberDepartment of Translational Oncology, Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany.
Anna M SokolBiomolecular Mass Spectrometry, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.
Andrea NistGenomics Core Facility, Philipps University, Marburg, Germany.
Thorsten StieweGenomics Core Facility, Philipps University, Marburg, Germany.
Imke BullwinkelDepartment of Translational Oncology, Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany.
Florian FinkernagelDepartment of Translational Oncology, Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany.
Silke ReinartzDepartment of Translational Oncology, Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany.
Sabine Müller-BrüsselbachDepartment of Translational Oncology, Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany.
Robert GrosseInstitut for Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs University, Freiburg, Germany.
Johannes GraumannBiomolecular Mass Spectrometry, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.
Rolf MüllerDepartment of Translational Oncology, Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany.
Philipps University of Marburg · DEMax Planck Institute for Heart and Lung Research · DEUniversity of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lysophosphatidic acid (LPA) species accumulate in the ascites of ovarian high-grade serous cancer (HGSC) and are associated with short relapse-free survival. LPA is known to support metastatic spread of cancer cells by activating a multitude of signaling pathways via G-protein-coupled receptors of the LPAR family. Systematic unbiased analyses of the LPA-regulated signal transduction network in ovarian cancer cells have, however, not been reported to date.

Indexed as

ActomyosinOvarian NeoplasmsCell MovementEntosisFemaleHumansLysophospholipidsNeoplasm Recurrence, LocalSignal TransductionActomyosinlysophosphatidic acidLysophospholipidsDOCK7entosislysophosphatidic acidmigrationMYPT1

Identifiers

PMID37064875
PMCPMC10091871
OpenAlexW4364321806

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.