ArticleACS omega2023
Dissolvable Topical Formulations for Burst and Constant Delivery of Vitamin C.
Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Review
- Cyclodextrin-Based Delivery Systems in Cosmeceuticals: Current Advances and Future Perspectives.Biomolecules · 2026Review
- Vitamin C Conjugates in Biomedicine: A Comprehensive Exploration with Drugs, Polymers, Proteins, and Peptides.Mini reviews in medicinal chemistry · 2026Review
- Cyclodextrins and their potential applications for delivering vitamins, iron, and iodine for improving micronutrient status.Drug delivery and translational research · 2025Review
- Physicochemical Characterization and Kinetics Study of Polymer Carriers with Vitamin C for Controlled Release Applications.Materials (Basel, Switzerland) · 2024Article
- Plant-Based, Hydrogel-like Microfibers as an Antioxidant Platform for Skin Burn Healing.ACS applied bio materials · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Healthy skin has a high vitamin C concentration that protects against ultraviolet (UV)-induced damage, promotes wound healing, and lowers cancer risk. The present contribution describes two drug delivery systems for topical administration of vitamin C. The electrospun poly(vinyl alcohol) (PVA) nanofiber carrier of vitamin C exhibits a burst release profile (66 mg/g/h followed by 6.3 mg/g/h). In comparison, a new composite PVA nanofiber-molecular capsule delivers vitamin C at a constant rate (8.2 mg/g/h) with a zeroth-order release profile for better therapeutic management. Both delivery systems protect vitamin C and afford increased heat stability. The molecular capsules of β-cyclodextrin with the vitamin C inclusion complex are immobilized on cellulose acetate and electrosprayed onto an electrospun PVA nanofiber mat.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.