Evidence map›Paper›PMID 37066240›Full record

ArticlebioRxiv : the preprint server for biology2023

Increased response to immune checkpoint inhibitors with dietary methionine restriction.

Lauren C Morehead, Sarita Garg, Katherine F Wallis, Eric R Siegel, Alan J Tackett, Isabelle R Miousse

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lauren C MoreheadDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR.
Sarita GargDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR.
Katherine F WallisDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR.
Eric R SiegelDepartment of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR.
Alan J TackettDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR.
Isabelle R MiousseDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR.
University of Arkansas for Medical Sciences · US

Funding

Unraveling Gene-Environment Interactions Shaping Metabolism: A Multi-Omics Analysis in DrosophilaP20GM139768 · NIGMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI Narasimhan Rajaram · 2021 to 2026
$17.0M
Institutional Career DevelopmentKL2TR003108 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI ARTHUR, JOHN M., BORSHEIM, ELISABET · 2019 to 2023
$2.3M
Identification of Druggable Targets to Complement Melanoma TherapyR01CA236209 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI TACKETT, ALAN · 2019 to 2023
$1.7M
NCATS NIH HHS KL2 TR003108NCI NIH HHS R01 CA236209NIGMS NIH HHS P20 GM139768
6 · The paper itself

Abstract

Dietary methionine restriction, defined as reduction of methionine intake by around 80%, reproducibly decreases tumor growth and synergizes with cancer therapies. Here, we combined dietary methionine restriction with immune checkpoint inhibitors in a model of colon adenocarcinoma.

Identifiers

PMID37066240
PMCPMC10104076
OpenAlexW4362678121

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.