Evidence map›Paper›PMID 37066331›Full record

ArticlebioRxiv : the preprint server for biology2023

Interferon-gamma is Quintessential for NOS2 and COX2 Expression in ER

Robert Ys Cheng, Lisa A Ridnour, Adelaide L Wink, Ana L Gonzalez, Elise L Femino, Helene Rittscher, Veena Somasundarum, William F Heinz, Leandro Coutinho, M Cristina Rangel and 15 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 11 institutions in 3 countries.

Robert Ys Cheng
Lisa A Ridnour
Adelaide L Wink
Ana L Gonzalez
Elise L Femino
Helene Rittscher
Veena Somasundarum
William F Heinz
Leandro Coutinho
M Cristina Rangel
Elijah F Edmondson
Donna Butcher
Robert J Kinders
Xiaoxian Li
Stephen T C Wong
Daniel W McVicar
Steven K Anderson
Milind Pore
Stephen M Hewitt
Timothy R Billiar
Sharon Glynn
Jenny C Chang
Stephen J Lockett
Stefan Ambs
David A Wink
National Institutes of Health · USLeidos (United States) · USUniversidade de São Paulo · BRCenter for Cancer Research · USCornell University · USEmory University · USFrederick National Laboratory for Cancer Research · USHouston Methodist · USOffice of the Director · USOllscoil na Gaillimhe – University of Galway · IEUniversity of Pittsburgh Medical Center · US

Funding

Signal Transduction of Paired Inhibitory Receptors of NK Cells and MacrophagesZIABC010300 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MCVICAR, DANIEL W. · 2009 to 2025
$24.6M
6 · The paper itself

Abstract

A strong correlation between NOS2 and COX2 tumor expression and poor clinical outcomes in ER-breast cancer has been established. However, mechanisms of tumor induction of these enzymes are unclear. Analysis of The Cancer Genome Atlas (TCGA) revealed correlations between NOS2 and COX2 expression and Th1 cytokines. Herein, single cell RNAseq analysis of TNBC cells shows potent NOS2 and COX2 induction by IFNγ combined with IL1β or TNFα. Given that IFNγ is secreted by cytolytic lymphocytes, which improve clinical outcomes, this role of IFNγpresents a dichotomy. To explore this conundrum, tumor NOS2, COX2, and CD8

Identifiers

PMID37066331
PMCPMC10104135
OpenAlexW4362700661

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.