Evidence map›Paper›PMID 37068227›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

The mitochondrion of

Sethu C Nair, Justin T Munro, Alexis Mann, Manuel Llinás, Sean T Prigge

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Vesicular mechanisms of drug resistance in apicomplexan parasites.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  4. The essential genome ofScience (New York, N.Y.) · 2025
    Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sethu C NairDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21218.ORCID 0000-0002-0957-8699
Justin T MunroDepartment of Chemistry, Pennsylvania State University, University Park, PA 16802.
Alexis MannDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21218.
Manuel LlinásDepartment of Chemistry, Pennsylvania State University, University Park, PA 16802.ORCID 0000-0002-6173-5882
Sean T PriggeDepartment of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21218.ORCID 0000-0001-9684-1733
Johns Hopkins University · USPennsylvania State University · US

Funding

Determinants of apicoplast maintenance in malaria parasitesR01AI125534 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Sean Taylor PRIGGE · 2016 to 2026
$3.9M
Integrative Analysis of Metabolic Phenotypes (IAMP) Predoctoral Training ProgramT32DK120509 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PATTERSON, ANDREW, PERDEW, GARY H. · 2020 to 2024
$781k
NIAID NIH HHS R01 AI125534NIDDK NIH HHS T32 DK120509
6 · The paper itself

Abstract

Coenzyme A (CoA) biosynthesis is an excellent target for antimalarial intervention. While most studies have focused on the use of CoA to produce acetyl-CoA in the apicoplast and the cytosol of malaria parasites, mitochondrial acetyl-CoA production is less well understood. In the current study, we performed metabolite-labeling experiments to measure endogenous metabolites in

Indexed as

MitochondriaPlasmodium falciparumAcetylationAcetyl Coenzyme AOxidoreductasesAcetyl Coenzyme AOxidoreductasesacetylationacetyl-CoAlipoic acidmalaria parasitesmitochondrion

Identifiers

PMID37068227
PMCPMC10151609
OpenAlexW4366140575

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.