Evidence map›Paper›PMID 37068249›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

The human malaria parasite

Victoria M Schneider, Joseph E Visone, Chantal T Harris, Francesca Florini, Evi Hadjimichael, Xu Zhang, Mackensie R Gross, Kyu Y Rhee, Choukri Ben Mamoun, Björn F C Kafsack and 1 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Article
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  10. Variable surface antigen expression, virulence, and persistent infection byMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  11. AeLife · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Review
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  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Victoria M SchneiderDepartment of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, Ithaca, NY 14853.
Joseph E VisoneDepartment of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, Ithaca, NY 14853.
Chantal T HarrisDepartment of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, Ithaca, NY 14853.
Francesca FloriniDepartment of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, Ithaca, NY 14853.
Evi HadjimichaelDepartment of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, Ithaca, NY 14853.
Xu ZhangDepartment of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, Ithaca, NY 14853.
Mackensie R GrossDepartment of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, Ithaca, NY 14853.
Kyu Y RheeDepartment of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, Ithaca, NY 14853.
Choukri Ben MamounSection of Infectious Disease, Department of Microbial Pathogenesis, Yale School of Medicine, Yale University New Haven, CT 06510.ORCID 0000-0001-5028-1400
Björn F C KafsackDepartment of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, Ithaca, NY 14853.ORCID 0000-0003-0089-1096
Kirk W DeitschDepartment of Microbiology and Immunology, Weill Cornell Medicine, Cornell University, Ithaca, NY 14853.ORCID 0000-0002-9183-2480
Cornell University · USYale University · US

Funding

Var gene regulation and antigenic variation in malariaR01AI052390 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEITSCH, KIRK W · 2002 to 2019
$6.6M
Mechanisms of environmental sensing and responses by malaria parasitesR01AI138499 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEITSCH, KIRK W · 2018 to 2022
$3.7M
A structured transcriptional switching network that coordinates antigenic variation by malaria parasitesR01AI161299 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI Kirk W Deitsch · 2021 to 2026
$3.4M
Regulation of Sexual Differentiation in Malaria ParasitesR01AI141965 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI KAFSACK, BJORN FELIX CAESAR · 2019 to 2023
$2.8M
DNA repair and recombination within the var gene family of P. falciparumR01AI099327 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEITSCH, KIRK W · 2012 to 2016
$2.2M
A Molecular Switch Controlling Antigenic Variation in Malaria ParasitesF31AI164897 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI VISONE, JOSEPH EDWARD · 2022 to 2024
$143k
Mechanisms Governing Expression of AP2-G, the Master Regulator of Sexual Differentiation in Malaria ParasitesF31AI136405 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI HARRIS, CHANTAL · 2018 to 2020
$135k
NIAID NIH HHS F31 AI136405NIAID NIH HHS F31 AI164897NIAID NIH HHS R01 AI052390NIAID NIH HHS R01 AI099327NIAID NIH HHS R01 AI138499NIAID NIH HHS R01 AI141965NIAID NIH HHS R01 AI161299
6 · The paper itself

Abstract

The primary antigenic and virulence determinant of the human malaria parasite

Indexed as

Malaria, FalciparumParasitesAnimalsAntigenic VariationGene Expression RegulationHumansPlasmodium falciparumProtozoan ProteinsProtozoan Proteinsgene expressionimmune evasionmetabolismmethylationvar genes

Identifiers

PMID37068249
PMCPMC10151525
OpenAlexW4366140616

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.