ArticleScientific reports2023
A whole-brain model of the neural entropy increase elicited by psychedelic drugs.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Neural complexity is increased after low doses of LSD, but not moderate to high doses of oral THC or methamphetamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- Psychedelics align brain activity with context.Nature · 2026Article
- Psilocybin shapes the slow, global propagation of brain activity over the cortical layout of 5HT2a receptors.Communications biology · 2026Article
- Restoring oscillatory dynamics in Alzheimer's disease: A laminar whole-brain model of serotonergic psychedelic effects.Network neuroscience (Cambridge, Mass.) · 2026Article
- Brain state theory as a comprehensive model for addressing the "non-eloquent" brain in glioma surgery.Journal of neuro-oncology · 2025Article
- The Role of Psychedelics in Contemporary Psychological and Interdisciplinary Inquiry.Journal of personalized medicine · 2025Review
- A computational approach to evaluate how molecular mechanisms impact large-scale brain activity.Nature computational science · 2025Article
- Transient destabilization of whole brain dynamics induced by N,N-Dimethyltryptamine (DMT).Communications biology · 2025Article
- Psilocybin-assisted psychotherapy for Parkinson's disease without depression: A case-report.Journal of Parkinson's disease · 2025Article
- Entropy and Complexity Tools Across Scales in Neuroscience: A Review.Entropy (Basel, Switzerland) · 2025Review
- The Algorithmic Agent Perspective and Computational Neuropsychiatry: From Etiology to Advanced Therapy in Major Depressive Disorder.Entropy (Basel, Switzerland) · 2024Article
- Dynamical structure-function correlations provide robust and generalizable signatures of consciousness in humans.Communications biology · 2024Article
- Beyond the usual suspects: multi-factorial computational models in the search for neurodegenerative disease mechanisms.Translational psychiatry · 2024Review
- Whole brain modelling for simulating pharmacological interventions on patients with disorders of consciousness.Communications biology · 2024Article
- Psilocybin enhances insightfulness in meditation: a perspective on the global topology of brain imaging during meditation.Scientific reports · 2024Article
- Neurophysiological treatment effects of mesdopetam, pimavanserin and clozapine in a rodent model of Parkinson's disease psychosis.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Article
- Effects of External Stimulation on Psychedelic State Neurodynamics.ACS chemical neuroscience · 2024Article
- High-Density Exploration of Activity States in a Multi-Area Brain Model.Neuroinformatics · 2024Article
- Neural mass modeling for the masses: Democratizing access to whole-brain biophysical modeling with FastDMF.Network neuroscience (Cambridge, Mass.) · 2024Article
- Psychedelics in developmental stuttering to modulate brain functioning: a new therapeutic perspective?Frontiers in human neuroscience · 2024Article
Corrections and comments
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Authors and funding
8 authors at 8 institutions in 7 countries.
Funding
Abstract
Psychedelic drugs, including lysergic acid diethylamide (LSD) and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought to be of relevance to the psychedelic experience, mediating both acute alterations in consciousness and long-term effects. However, no clear mechanistic explanation for this entropy increase has been put forward so far. We sought to do this here by building upon a recent whole-brain model of serotonergic neuromodulation, to study the entropic effects of 5HT2A-R activation. Our results reproduce the overall entropy increase observed in previous experiments in vivo, providing the first model-based explanation for this phenomenon. We also found that entropy changes were not uniform across the brain: entropy increased in all regions, but the larger effect were localised in visuo-occipital regions. Interestingly, at the whole-brain level, this reconfiguration was not well explained by 5HT2A-R density, but related closely to the topological properties of the brain's anatomical connectivity. These results help us understand the mechanisms underlying the psychedelic state and, more generally, the pharmacological modulation of whole-brain activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.