ArticleScientific reports2023
Circulating proteins to predict COVID-19 severity.
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 19 citations in OpenAlex.
- Integrated miR-omics and proteomics reveal the regulatory role of miR in protein networks associated with COVID-19 disease progression.Frontiers in immunology · 2026Article
- Unraveling the COVID-19 Severity Hubs and Interplays in Inflammatory-Related RNA-Protein Networks.International journal of molecular sciences · 2025Article
- Proteomic signatures of vaccine-induced and breakthrough infection-induced host responses to SARS-CoV-2.Vaccine · 2025Article
- Serum proteomics and machine learning identify PSMD11 as a prognostic biomarker in severe fever with thrombocytopenia syndrome.Frontiers in immunology · 2025Article
- Antibodies to the RBD of SARS-CoV-2 spike mediate productive infection of primary human macrophages.Nature communications · 2024Article
- Longitudinal analysis of the lung proteome reveals persistent repair months after mild to moderate COVID-19.Cell reports. Medicine · 2024Article
- Proteomics validate circulating GDF-15 as an independent biomarker for COVID-19 severity.Frontiers in immunology · 2024Article
- Extracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity.Frontiers in immunology · 2024Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
66 authors at 12 institutions in 6 countries.
Chen-Yang Su *Lady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Sirui Zhou *Lady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Edgar Gonzalez-Kozlova *Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Guillaume Butler-LaporteLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Elsa Brunet-RatnasinghamResearch Centre of the Centre Hospitalier de L'Université de Montréal, Montreal, QC, Canada.
Tomoko NakanishiLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Wonseok JeonDepartment of Computer Science, McGill University, Montréal, QC, Canada.
David R MorrisonLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Laetitia LaurentLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Jonathan AfilaloLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Marc AfilaloDepartment of Emergency Medicine, Jewish General Hospital, McGill University, Montreal, QC, Canada.
Danielle HenryLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Yiheng ChenLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Julia Carrasco-ZaniniMRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Yossi FarjounLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Maik PietznerMRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Nofar KimchiLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Zaman AfrasiabiLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Nardin RezkLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Meriem BouabLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Louis PetitjeanLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Charlotte GuzmanLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Xiaoqing XueLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Chris TseliosLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Branka VulesevicLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Olumide AdeleyeLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Tala AbdullahLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Noor AlmamloukLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Yara MoussaLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Chantal DeLucaLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Naomi DugganLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Erwin SchurrInfectious Diseases and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montréal, QC, Canada.
Nathalie BrassardResearch Centre of the Centre Hospitalier de L'Université de Montréal, Montreal, QC, Canada.
Madeleine DurandResearch Centre of the Centre Hospitalier de L'Université de Montréal, Montreal, QC, Canada.
Diane Marie Del VallePrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ryan ThompsonGenetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mario A CedilloDepartment of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Eric SchadtGenetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kai NieHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nicole W SimonsGenetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Konstantinos MouskasGenetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nicolas ZakiHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Manishkumar PatelPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hui XieHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jocelyn HarrisHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Robert MarvinHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Esther ChengGenetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kevin TuballesPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kimberly ArguetaHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ieisha ScottHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mount Sinai COVID-19 Biobank Team
Celia M T GreenwoodLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Clare PatersonSomaLogic Operating Co., Inc., Boulder, CO, USA.
Michael A HinterbergSomaLogic Operating Co., Inc., Boulder, CO, USA.
Claudia LangenbergMRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Vincenzo ForgettaLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada.
Joelle PineauDepartment of Computer Science, McGill University, Montréal, QC, Canada.
Vincent MooserDepartment of Human Genetics, McGill University, Montreal, QC, Canada.
Thomas MarronImmunotherapy and Phase 1 Trials, Mount Sinai Hospital, New York, NY, USA.
Noam D BeckmannGenetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Seunghee Kim-SchulzeHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alexander W CharneyMount Sinai Clinical Intelligence Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sacha GnjaticDepartment of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Daniel E KaufmannResearch Centre of the Centre Hospitalier de L'Université de Montréal, Montreal, QC, Canada.
Miriam MeradPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
J Brent RichardsLady Davis Institute for Medical Research, Jewish General Hospital, Pavilion H-413, 3755 Côte-Ste-Catherine Montréal, Montreal, QC, H3T 1E2, Canada. brent.richards@mcgill.ca.
Jewish General Hospital · CAIcahn School of Medicine at Mount Sinai · USUniversity of Cambridge · GBCentre Hospitalier de l’Université de Montréal · CAMcGill University · CAKing's College London · GBMount Sinai Hospital · USJapan Society for the Promotion of Science · JPMcGill University Health Centre · CASomaLogic (United States) · USUniversité de Montréal · CAUniversity Hospital of Lausanne · CH
Funding
THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ramon E Parsons · 2015 to 2026
$35.4MHigh-Dimensional Immune Monitoring of NCI-Supported Immunotherapy TrialsU24CA224319 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Sacha Gnjatic, Seunghee Kim-Schulze · 2017 to 2026
$21.5MCharacterizing and predicting colitis in immune checkpoint blockade-treated cancer patientsU01DK124165 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI COLOMBEL, JEAN-FREDERIC, FAITH, JEREMIAH JAMES · 2020 to 2024
$2.9MCOVID and Translational Science supercomputer (CATS)S10OD030463 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2021 to 2021
$2.0MBig Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0MCancer Research UK C18281/A29019Department of HealthMedical Research Council MC_UU_00006/1NCI NIH HHS P30 CA196521NCI NIH HHS U24 CA224319NIDDK NIH HHS U01 DK124165NIH HHS S10 OD026880NIH HHS S10 OD030463Wellcome Trust
Abstract
Predicting COVID-19 severity is difficult, and the biological pathways involved are not fully understood. To approach this problem, we measured 4701 circulating human protein abundances in two independent cohorts totaling 986 individuals. We then trained prediction models including protein abundances and clinical risk factors to predict COVID-19 severity in 417 subjects and tested these models in a separate cohort of 569 individuals. For severe COVID-19, a baseline model including age and sex provided an area under the receiver operator curve (AUC) of 65% in the test cohort. Selecting 92 proteins from the 4701 unique protein abundances improved the AUC to 88% in the training cohort, which remained relatively stable in the testing cohort at 86%, suggesting good generalizability. Proteins selected from different COVID-19 severity were enriched for cytokine and cytokine receptors, but more than half of the enriched pathways were not immune-related. Taken together, these findings suggest that circulating proteins measured at early stages of disease progression are reasonably accurate predictors of COVID-19 severity. Further research is needed to understand how to incorporate protein measurement into clinical care.
Indexed as
COVID-19Disease ProgressionHumansProteinsRetrospective StudiesRisk FactorsProteins
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What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.