Evidence map›Paper›PMID 37072435›Full record

ArticleScientific reports2023

Pulse wave and vector flow Imaging for atherosclerotic disease progression in hypercholesterolemic swine.

Paul Kemper, Grigorios M Karageorgos, Daniella Fodera, Nicole Lee, Nirvedh Meshram, Rachel A Weber, Pierre Nauleau, Nima Mobadersany, Nancy Kwon, Kristin Myers and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Paul KemperDepartment of Biomedical Engineering, Columbia University, New York, 10027, USA. ppk2111@columbia.edu.
Grigorios M KarageorgosDepartment of Biomedical Engineering, Columbia University, New York, 10027, USA.
Daniella FoderaDepartment of Biomedical Engineering, Columbia University, New York, 10027, USA.
Nicole LeeDepartment of Mechanical Engineering, Columbia University, New York, 10027, USA.
Nirvedh MeshramDepartment of Biomedical Engineering, Columbia University, New York, 10027, USA.
Rachel A WeberDepartment of Biomedical Engineering, Columbia University, New York, 10027, USA.
Pierre NauleauDepartment of Biomedical Engineering, Columbia University, New York, 10027, USA.
Nima MobadersanyDepartment of Biomedical Engineering, Columbia University, New York, 10027, USA.
Nancy KwonDepartment of Biomedical Engineering, Columbia University, New York, 10027, USA.
Kristin MyersDepartment of Mechanical Engineering, Columbia University, New York, 10027, USA.
Elisa E KonofagouDepartment of Biomedical Engineering, Columbia University, New York, 10027, USA. ek2191@columbia.edu.
Columbia University · US

Funding

Carotid plaque assessment using Pulse Wave ImagingR01HL135734 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KONOFAGOU, ELISA E. · 2017 to 2020
$2.5M
NHLBI NIH HHS R01 HL135734
6 · The paper itself

Abstract

Non-invasive monitoring of atherosclerosis remains challenging. Pulse Wave Imaging (PWI) is a non-invasive technique to measure the local stiffness at diastolic and end-systolic pressures and quantify the hemodynamics. The objective of this study is twofold, namely (1) to investigate the capability of (adaptive) PWI to assess progressive change in local stiffness and homogeneity of the carotid in a high-cholesterol swine model and (2) to assess the ability of PWI to monitor the change in hemodynamics and a corresponding change in stiffness. Nine (n=9) hypercholesterolemic swine were included in this study and followed for up to 9 months. A ligation in the left carotid was used to cause a hemodynamic disturbance. The carotids with detectable hemodynamic disturbance showed a reduction in wall shear stress immediately after ligation (2.12 ± 0.49 to 0.98 ± 0.47 Pa for 40-90% ligation (Group B) and 1.82 ± 0.25 to 0.49 ± 0.46 Pa for >90% ligation (Group C)). Histology revealed subsequent lesion formation after 8-9 months, and the type of lesion formation was dependent on the type of the induced ligation, with more complex plaques observed in the carotids with a more significant ligation (C: >90%). The compliance progression appears differed for groups B and C, with an increase in compliance to 2.09 ± 2.90×10

Indexed as

AtherosclerosisPlaque, AtheroscleroticAnimalsCarotid ArteriesDiagnostic ImagingDisease ProgressionSwine

Identifiers

PMID37072435
PMCPMC10113229
OpenAlexW4366335493

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.