Evidence map›Paper›PMID 37072609›Full record

ReviewFunctional & integrative genomics2023

Emerging roles of non-coding RNAs in psoriasis pathogenesis.

Debakreeta Ghosh, Torsa Ganguly, Raghunath Chatterjee

Abstract readReview
PubMed Publisher
In one paragraph

Review in Functional & integrative genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Debakreeta GhoshHuman Genetics Unit, Indian Statistical Institute, 203 B T Road, Kolkata, 700 108, India.
Torsa GangulyHuman Genetics Unit, Indian Statistical Institute, 203 B T Road, Kolkata, 700 108, India.
Raghunath ChatterjeeHuman Genetics Unit, Indian Statistical Institute, 203 B T Road, Kolkata, 700 108, India. rchatterjee@isical.ac.in.
Indian Statistical Institute · IN

Funding

Science and Engineering Research Board CRG/2020/003837
6 · The paper itself

Abstract

Psoriasis is a complex genetic skin disorder typically manifested by red, scaly, and itchy plaques most commonly over the scalp, trunk, elbows, and knees. Histopathological features include thickening of the epidermal layer due to hyper-proliferation and abnormal differentiation of epidermal keratinocytes along with infiltration of immune cells in the psoriatic skin. It is a chronic inflammatory relapsing disease, and there is currently no permanent cure for psoriasis. Proper medications can reduce the severity of the disease and improve the quality of life of the patients. While the genetic components of psoriasis pathogenesis are well explored, the full understanding of its epigenetic component remains elusive. Non-coding RNAs (ncRNAs) are documented to regulate various epigenetic processes that lead to the pathogenesis of different diseases including psoriasis. In this review, we have discussed the molecular interplay of different ncRNAs in psoriasis pathogenesis. The roles of microRNAs (miRNAs) in psoriasis are pretty well studied, whereas the roles of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) are emerging. This review provides ideas covering some of the latest findings of different modes of functions played by those different ncRNAs documented in the literature. As an ever-evolving topic, some works are still ongoing as well as there are several fields that need rigorous scientific ventures. We have proposed the areas which claim more explorations to better understand the roles played by the ncRNAs in psoriasis pathogenesis.

Indexed as

MicroRNAsPsoriasisRNA, Long NoncodingHumansQuality of LifeRNA, UntranslatedSkinMicroRNAsRNA, Long NoncodingRNA, UntranslatedCircular RNAKeratinocyteLong noncoding RNAMicroRNAPiwi-interacting RNAPsoriasis

Identifiers

PMID37072609
OpenAlexW4366351598

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.