ArticleBMC musculoskeletal disorders2023
Association between serum uric acid levels and bone mineral density in patients with osteoporosis: a cross-sectional study.
Article in BMC musculoskeletal disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- A Novel Approach to Determining Bone Loss Through Serum Uric Acid Levels: A Retrospective Multicenter Cohort Analysis.Journal of clinical medicine · 2026Article
- Association between serum uric acid levels and osteoporosis risk: evidence from a cross-sectional study and Mendelian randomization analysis.Clinical rheumatology · 2026Article
- Colchicine Suppresses Adipogenic Differentiation of Mesenchymal Stem Cells: Implications for Bone Adiposity Control.Pharmaceutics · 2026Article
- Association of uric acid, calcium, and creatinine with bone mineral density in adults over 50: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Influence of serum uric acid on bone mineral density across body mass index categories in men with type 2 diabetes: a cross-sectional study.BMC musculoskeletal disorders · 2025Article
- Exploration of purine metabolism-related genes in the development of osteoporosis by integrated analyses and experiments.European journal of medical research · 2025Article
- Associations between serum JAML, nesfatin-1, and 25(OH)D and the risk of diabetic kidney disease in patients with type 2 diabetes.Scientific reports · 2025Article
- The triangular relationship of serum uric acid, osteoporosis or osteopenia, and body mass index for men and postmenopausal women.Scientific reports · 2025Article
- The dual association of serum uric acid with the functional outcomes of patients after hip arthroplasty: 1-year follow-up study.Frontiers in surgery · 2025Article
- Development of a machine learning-based predictive model for osteoporosis risk and its application in clinical decision support.Frontiers in medicine · 2025Article
- U-Shaped association between apolipoprotein A1 and serum uric acid levels in patients with osteoporotic fractures: a cross-sectional study.Frontiers in endocrinology · 2025Article
- The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms.Frontiers in endocrinology · 2025Review
- The risk factors determined by four machine learning methods for the change of difference of bone mineral density in post-menopausal women after three years follow-up.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
8 authors.
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Abstract
backgroundThe results of studies exploring the association between serum uric acid (SUA) and bone mineral density (BMD) have been controversial and inconsistent. We thus sought to explore whether SUA levels were independently associated with BMD in patients with osteoporosis (OP).
methodsThis cross-sectional analysis was conducted using prospectively obtained data from the Affiliated Kunshan Hospital of Jiangsu University database pertaining to 1,249 OP patients that were hospitalized from January 2015 - March 2022. BMD was the outcome variable for this study, while baseline SUA levels were the exposure variable. Analyses were adjusted for a range of covariates including age, gender, body mass index (BMI) and a range of other baseline laboratory and clinical findings.
resultsSUA levels and BMD were independently positively associated with one another in OP patients. Following adjustment for age, gender, BMI, blood urae nitrogen (BUN), and 25(OH)D levels, a 0.0286 g/cm
conclusionsThese analyses revealed SUA levels to be independently positively associated with BMD in OP patients, with an additional non-linear relationship between these two variables being evident for individuals of normal or low body weight. This suggests that SUA levels may exert a protective effect on BMD at concentrations below 296 μmol/L in normal- and low-weight OP patients, whereas SUA levels above this concentration were unrelated to BMD.
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