Evidence map›Paper›PMID 37072843›Full record

Observational studyBMC oral health2023

Identification and susceptibility testing of oral candidiasis in advanced cancer patients.

Ragnhild Elisabeth Monsen, Anne Karin Kristoffersen, Caryl L Gay, Bente Brokstad Herlofson, Katrine Gahre Fjeld, Lene Hystad Hove, Hilde Nordgarden, Anita Tollisen, Anners Lerdal, Morten Enersen

Registry-linked trialOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02067572 (A Comparison of the Effectiveness of Normal Saline Mouthwash and Mouthwash Based on Tea Solution From Salvia Officinalis), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02067572 nacompletednot on this map

A Comparison of the Effectiveness of Normal Saline Mouthwash and Mouthwash Based on Tea Solution From Salvia Officinalis (SO) in Palliative Care. A Randomized Controlled Trial

TypeinterventionalSponsorLovisenberg Diakonale HospitalRan2014 to 2016Enrolled88ConditionsTerminal Illness, XerostomiaArmsSaline mouthwash, Salvia mouthwash
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Ragnhild Elisabeth MonsenDepartment for Interdisciplinary Health Sciences, Institute of Health and Society, Faculty of Medicine, University of Oslo, Postboks 1089 Blindern, 0317, Oslo, Norway. ragnhm@uio.no.
Anne Karin KristoffersenInstitute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Caryl L GayDepartment of Research, Lovisenberg Diaconal Hospital, Oslo, Norway.
Bente Brokstad HerlofsonDepartment of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Katrine Gahre FjeldDepartment of Cariology and Gerodontology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Lene Hystad HoveDepartment of Cariology and Gerodontology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Hilde NordgardenNational Resource Centre for Oral Health in Rare Disorders, Lovisenberg Diaconal Hospital, Oslo, Norway.
Anita TollisenUnger-Vetlesens Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.
Anners LerdalDepartment for Interdisciplinary Health Sciences, Institute of Health and Society, Faculty of Medicine, University of Oslo, Postboks 1089 Blindern, 0317, Oslo, Norway.
Morten EnersenInstitute of Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
University of Oslo · NOLovisenberg Diakonale Høgskole · NOLovisenberg Diakonale Sykehus · NOUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with advanced cancer are prone to develop different opportunistic oral infection due to anti-cancer treatment or the malignancies themselves. Studies of oral fungal samples show an increased prevalence of non-Candida albicans species in mixed oral infections with Candida albicans. Non-C. albicans and C. albicans are associated with varying degrees of resistance to azoles, which may have implications for treatment. This study aimed to assess the diversity and antifungal susceptibility of Candida species detected in the oral cavity.

methodsAn observational study with microbiological analysis was conducted. Clinical fungal isolates were collected from patients in a hospice unit in 2014-2016. Isolates were re-grown on chromID® Candida plates in 2020. Single colony of each species was re-cultivated and prepared for biochemical identification with a VITEK2® system and verified by gene sequencing. Etest was performed on RPMI agar, and the antifungals fluconazole, amphotericin B, anidulafungin and nystatin were applied.

resultsFifty-six isolates from 45 patients were identified. Seven different Candida species and one Saccharomyces species were detected. The results of biochemical identification were confirmed with sequencing analysis. Thirty-six patients had mono infection, and nine out of 45 patients had 2-3 different species detected. Of C. albicans strains, 39 out of 40 were susceptible to fluconazole. Two non-C. albicans species were resistant to fluconazole, one to amphotericin B and three to anidulafungin.

conclusionC. albicans was the predominant species, with a high susceptibility to antifungal agents. Different Candida species occur in both mono and mixed infections. Identification and susceptibility testing may therefore lead to more effective treatment and may prevent the development of resistance among patients with advanced cancer. TRAIL REGISTRATION: The study Oral Health in Advanced Cancer was registered at ClinicalTrials.gov (#NCT02067572) in 20/02/2014.

Indexed as

Candidiasis, OralNeoplasmsAmphotericin BAnidulafunginAntifungal AgentsCandidaCandida albicansDrug Resistance, FungalFluconazoleHumansMicrobial Sensitivity TestsAmphotericin BAnidulafunginAntifungal AgentsFluconazoleAdvanced cancerCandida carriageCandidiasisEtestFungalOralPolyfungal infection

Identifiers

PMID37072843
PMCPMC10111683
OpenAlexW4366280076

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.