Evidence map›Paper›PMID 37073619›Full record

ArticleActa obstetricia et gynecologica Scandinavica2023

Maternal traditional Chinese medicine exposure and risk of congenital malformations: a multicenter prospective cohort study.

Ting Peng, Lin-Liang Yin, Yu Xiong, Feng Xie, Chun-Ya Ji, Zhong Yang, Qi Pan, Ming-Qing Li, Xue-Dong Deng, Jing Dong and 1 more

RetractedOpen access · diamondAbstract readMulticenter StudyRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta obstetricia et gynecologica Scandinavica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Ting PengDepartment of Obstetrics, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Lin-Liang YinCenter for Medical Ultrasound, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China.
Yu XiongDepartment of Obstetrics, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Feng XieMedical Center of Diagnosis and Treatment for Cervical Disease, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Chun-Ya JiCenter for Medical Ultrasound, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China.
Zhong YangCenter for Medical Ultrasound, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China.
Qi PanCenter for Medical Ultrasound, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China.
Ming-Qing LiDepartment of Obstetrics, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.
Xue-Dong DengCenter for Medical Ultrasound, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China.
Jing DongMedical Center of Diagnosis and Treatment for Cervical Disease, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Jiang-Nan WuShanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai, China.ORCID 0000-0003-4378-2391
Suzhou Municipal Hospital · CNState Key Laboratory of Oncogene and Related Genes · CNObstetrics and Gynecology Hospital of Fudan University · CN

Funding

National Natural Science Foundation of China 81671484
6 · The paper itself

Abstract

introductionThe potential teratogenic risk of traditional Chinese medicine (TCM) is of widespread concern; however, related evidence is largely absent in humans. This study aimed to compare the prevalence of congenital malformations between pregnant women with and without TCM exposure. MATERIAL AND

methodsThis was a multicenter prospective cohort study of 17 713 women who participated in a survey on periconceptional TCM exposure. Primary outcome was congenital malformations diagnosed from a survey conducted on the day 42 after delivery.

resultsA total of 16 751 pregnant women with 273 congenital malformations were included in the analysis. Fetuses exposed to TCM had an increased risk of congenital malformations compared to those without exposure (odds ratio [OR] 2.10; 95% confidence interval [CI] 1.09-4.02) after controlling for potential confounders. There were significant associations with congenital malformations in women with early pregnant exposure (OR 2.04, 95% CI 1.00-4.20) and for those who received ≥2 TCM formulas (OR 5.84, 95% CI 1.44-23.65). Pre-pregnancy TCM exposure was significantly associated with an increased risk of congenital heart defects (OR 12.69; 95% CI 3.01-53.51).

conclusionsPericonceptional TCM exposure is associated with an increased risk of congenital malformation. This effect was cumulative and sensitive to periconceptional age. Therefore, TCM deserves more attention and should be used cautiously for pregnant women and those trying to become pregnant.

Indexed as

Abnormalities, Drug-InducedCongenital AbnormalitiesHeart Defects, CongenitalPregnancy ComplicationsFemaleHumansMaternal ExposureMedicine, Chinese TraditionalPregnancyProspective Studiescohort studycongenital heart defectscongenital malformationsSpatholobi caulisSpatholobus suberectustraditional Chinese medicine

Identifiers

PMID37073619
PMCPMC10201976
OpenAlexW4366351473

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.