Evidence map›Paper›PMID 37076504›Full record

ArticleScientific reports2023

Dentin defects caused by a Dspp

Tian Liang, Charles E Smith, Yuanyuan Hu, Hong Zhang, Chuhua Zhang, Qian Xu, Yongbo Lu, Ling Qi, Jan C-C Hu, James P Simmer

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Beyond the diagnosis: UnravelingThe Japanese dental science review · 2026
    Review
  2. Citrate Transporter NaCT and Enamel Mineralization: TheInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. [Case report of dentinogenesis imperfecta and review of literature].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025
    Review
  7. Functions of secretory calcium-binding phosphoproteins in dental mineralization.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Tian LiangDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI, 48109-1078, USA. tianl@umich.edu.
Charles E SmithDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI, 48109-1078, USA.
Yuanyuan HuDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI, 48109-1078, USA.
Hong ZhangDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI, 48109-1078, USA.
Chuhua ZhangDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI, 48109-1078, USA.
Qian XuDepartment of Biomedical Sciences and Center for Craniofacial Research and Diagnosis, Texas A&M University College of Dentistry, 3302 Gaston Ave., Dallas, TX, 75246, USA.
Yongbo LuDepartment of Biomedical Sciences and Center for Craniofacial Research and Diagnosis, Texas A&M University College of Dentistry, 3302 Gaston Ave., Dallas, TX, 75246, USA.
Ling QiDepartment of Molecular & Integrative Physiology, Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, 1000 Wall St., Ann Arbor, MI, 48105, USA.
Jan C-C HuDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI, 48109-1078, USA.
James P SimmerDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI, 48109-1078, USA.
University of Michigan–Ann Arbor · USTexas A&M University · US

Funding

DSPP Function, Pathophysiology, and Genetic DiagnosisR01DE027675 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SIMMER, JAMES P · 2018 to 2022
$2.4M
Dentin Sialophosphoprotein (DSPP) and Unfolded Protein Response (UPR) in Dentinogenesis Imperfecta (DGI) and Odontoblast FunctionR01DE027345 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI LU, YONGBO, QIN, CHUNLIN · 2018 to 2022
$1.8M
Ameloblast-specific mineral ribbon attachment/elongation complex in enamel formationR00DE030858 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TIAN LIANG · 2024 to 2026
$747k
Leica SP8 Confocal MicroscopeS10OD028612 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ANTONETTI, DAVID · 2021 to 2021
$599k
Ameloblast-specific mineral ribbon attachment/elongation complex in enamel formationK99DE030858 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIANG, TIAN · 2022 to 2023
$203k
NIDCR NIH HHS K99 DE030858NIDCR NIH HHS R00 DE030858NIDCR NIH HHS R01 DE027345NIDCR NIH HHS R01 DE027675NIH HHS S10 OD028612
6 · The paper itself

Abstract

Dentin sialophosphoprotein (DSPP) is primarily expressed by differentiated odontoblasts (dentin-forming cells), and transiently expressed by presecretory ameloblasts (enamel-forming cells). Disease-causing DSPP mutations predominantly fall into two categories: 5' mutations affecting targeting and trafficking, and 3' - 1 frameshift mutations converting the repetitive, hydrophilic, acidic C-terminal domain into a hydrophobic one. We characterized the dental phenotypes and investigated the pathological mechanisms of Dspp

Indexed as

Extracellular Matrix ProteinsFrameshift MutationAnimalsAutophagyDentinHumansMiceMutationOdontoblastsPhosphoproteinsSialoglycoproteinsExtracellular Matrix ProteinsPhosphoproteinsSialoglycoproteins

Identifiers

PMID37076504
PMCPMC10115861
OpenAlexW4366390297

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.