ArticleFrontiers in endocrinology2023
The causal effect of obesity on diabetic retinopathy: A two-sample Mendelian randomization study.
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Genetically mimicked effects of thyroid dysfunction on diabetic retinopathy risk: a 2-sample univariable and multivariable Mendelian randomization study.Frontiers in endocrinology · 2024Pooled it
- Body Mass Index is Associated With Direction-Specific Increases in With-the-Rule Corneal and Refractive Astigmatism in Schoolchildren.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Causal association between circulating leukocyte characteristics and diabetic retinopathy based on two-sample Mendelian randomization.Journal of diabetes investigation · 2026Article
- Nonlinear relationship between serum ferritin and diabetic retinopathy in patients with type 2 diabetes mellitus: mediating role of neutrophil-to-albumin ratio.Frontiers in endocrinology · 2026Article
- The Relationship Between Body Fat Percentage, Anthropometric Measurements, and Diabetes Complications in Female Patients with Type 2 Diabetes.Journal of clinical medicine · 2025Article
- Causal association between different types of ametropia and risk of diabetic retinopathy: a two-sample Mendelian randomization study.BMJ open ophthalmology · 2025Article
- Association between methylmalonic acid and composite dietary antioxidant index and diabetic retinopathy: data from National Health and Nutrition Examination Survey.Nutrition & metabolism · 2025Article
- Association of diabetic retinopathy with plasma atherosclerotic index, visceral obesity index, and lipid accumulation products: NHANES 2005-2008.Lipids in health and disease · 2024Article
- Article
- Causal influence of immune factors on the risk of diabetic retinopathy: a mendelian randomization study.Diabetology & metabolic syndrome · 2024Article
- Genetically identification of endometriosis and cancers risk in women through a two-sample Mendelian randomization study.Scientific reports · 2024Article
- Novel Antidiabetic Drugs and the Risk of Diabetic Retinopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of clinical medicine · 2024Review
- Causal relationships of lifestyle behaviours and body fat distribution on diabetic microvascular complications: a Mendelian randomization study.Frontiers in genetics · 2024Article
- Commentary: The causal effect of hypertension, intraocular pressure, and diabetic retinopathy: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The causal effect of obesity on diabetic retinopathy (DR) remains controversial. The aim of this study was to assess the causal association of generalized obesity evaluated by body mass index (BMI) and abdominal obesity evaluated by waist or hip circumference with DR, background DR, and proliferative DR using a two-sample Mendelian randomization (MR) analysis. Methods: Genetic variants associated with obesity at the genome-wide significance (P<5×10 Results: Genetically predicted increased BMI [OR=1.239; 95% CI=(1.134, 1.353);P=1.94×10 Conclusion: This study using two-sample MR analysis indicated that generalized obesity and abdominal obesity might increase the risk of any DR. These results suggested that controlling obesity may be effective in DR development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.