MicroRNA-27a Suppresses the Toxic Action of Mepivacaine on Breast Cancer Cells via Inositol-Requiring Enzyme 1-TNF Receptor-Associated Factor 2.

WenHong Fu, XiaoLing Hu, GengZhang Li, SongTao Liu

Open access · hybridAbstract read

In one paragraph

Article in Contrast media & molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 83% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

WenHong FuDepartment of Anesthesiology, Nanhua Hospital Affiliated to Nanhua University, ShaoYang 422001, Hunan Province, China.ORCID 0000-0001-9061-1435

XiaoLing HuDepartment of Anesthesiology, The First Affiliated Hospital of University of South China, Hengyang City 421000, Hunan Province, China.

GengZhang LiDepartment of Anesthesiology, Nanhua Hospital Affiliated to Nanhua University, ShaoYang 422001, Hunan Province, China.

SongTao LiuDepartment of Anesthesiology, Nanhua Hospital Affiliated to Nanhua University, ShaoYang 422001, Hunan Province, China.

University of South China · CNFirst Affiliated Hospital of University of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the toxic effects of microRNA-27a on breast cancer cells through inositol-acquiring enzyme 1-TNF receptor-associated factor 2 inhibition by mepivacaine. Methods: The elevation of miR-27a in MCF-7 of BCC lines was measured, and groups were set up as control, mepivacaine, and elevated groups. Cells from each group were examined for inflammatory progression. Results: Elevated miR-27a in MCF-7 cells was able to distinctly augment the cell advancement ( Conclusion: Elevated miR-27a in MCF-7 of BCC lineage was effective in reducing the toxic effects of mepivacaine on cells and enhancing cell progression. This mechanism is thought to be related to the activation of the IRE1-TRAF2 signaling pathway in BCC. The findings may provide a theoretical basis for targeted treatment of BC in clinical practice.

Indexed as

Breast NeoplasmsMicroRNAsApoptosisFemaleHumansMCF-7 CellsMepivacaineProtein Serine-Threonine KinasesTNF Receptor-Associated Factor 2MepivacaineMicroRNAsMIRN27 microRNA, humanProtein Serine-Threonine KinasesTNF Receptor-Associated Factor 2

Identifiers

PMID37078000

DOI10.1155/2023/1153034

PMCPMC10110387

OpenAlexW4363676838

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.