Evidence map›Paper›PMID 37078747›Full record

ArticleActa biochimica et biophysica Sinica2023

Transcriptome analysis reveals a potential regulatory mechanism of the lnc-5423.6/IGFBP5 axis in the early stages of mouse thymic involution.

Bingxin Li, Yaqiong Ye, Longsheng Hong, Wanyan Li, Qingru Wu, Wenjun Liu, Yongjiang Ma, Danning Xu, Yugu Li

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Bingxin LiCollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Yaqiong YeSchool of Life Science and Engineering, Foshan University, Foshan 528000, China.
Longsheng HongCollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Wanyan LiCollege of Animal Science & Technology, Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Qingru WuCollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Wenjun LiuCollege of Animal Science & Technology, Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Yongjiang MaCollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
Danning XuCollege of Animal Science & Technology, Guangdong Province Key Laboratory of Waterfowl Healthy Breeding, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Yugu LiCollege of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.
South China Agricultural University · CNFoshan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related thymic involution is one of the significant reasons for induced immunity decline. Recent evidence has indicated that lncRNAs are widely involved in regulating organ development. However, the lncRNA expression profiles in mouse thymic involution have not been reported. In this study, we collect mouse thymus at the ages of 1 month, 3 months, and 6 months for sequencing to observe the lncRNA and gene expression profiles in the early stages of thymic involution. Through bioinformatics analysis, a triple regulatory network of lncRNA-miRNA-mRNA that contains 29 lncRNAs, 145 miRNAs and 12 mRNAs that may be related to thymic involution is identified. Among them, IGFBP5 can reduce the viability, inhibit proliferation and promote apoptosis of mouse medullary thymic epithelial cell line 1 (MTEC1) cells through the p53 signaling pathway. In addition, miR-193b-3p can alleviate MTEC1 cell apoptosis by targeting

Indexed as

MicroRNAsRNA, Long NoncodingAnimalsCarrier ProteinsGene Expression ProfilingGene Regulatory NetworksMiceRNA, MessengerThymus GlandTranscriptomeCarrier ProteinsIGFBP5-interacting protein, mouseMicroRNAsRNA, Long NoncodingRNA, MessengerceRNAIGFBP5lnc-5423.6miR-193b-3pthymic involution

Identifiers

PMID37078747
PMCPMC10195152
OpenAlexW4323858330

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.