ArticleEnvironmental health perspectives2023
Individual, Independent, and Joint Associations of Toxic Metals and Manganese on Hypertensive Disorders of Pregnancy: Results from the MIREC Canadian Pregnancy Cohort.
Article in Environmental health perspectives, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Association of Blood Manganese and Preeclampsia: A Systematic Review and Meta-analysis.Biological trace element research · 2024Pooled it
- Arsenic Exposure During Pregnancy: Impacts to Maternal and Offspring Cardiovascular Health.Medical research archives · 2026Article
- Paired analysis of meconium and neonatal hair reveals distinct biomarker profiles of prenatal exposure to trace metal elements.Scientific reports · 2026Article
- An Exploration of Machine Learning Methods in Human Biomonitoring.International journal of environmental research and public health · 2026Review
- Environmental Determinants of Sleep and Hypertension: A Critical Review of Evidence and Mechanisms.Current hypertension reports · 2026Review
- DNA Methylation ofEnvironment & health (Washington, D.C.) · 2026Article
- Reproductive health characteristics among women living in severe poverty in urban Haiti.Reproductive health · 2025Observational
- Associations Between Blood Heavy Metal Concentrations and Hypertensive Disorders of Pregnancy in the Japan Environment and Children's Study.Journal of the American Heart Association · 2025Article
- Associations of Heavy Metals and Trace Elements with Gestational Diabetes Mellitus in the Boston Birth Cohort.Environmental science & technology · 2025Article
- The Association Between Pregnancy Complications and Long-term Maternal Cardiometabolic Health in the MIREC Cohort Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Article
- Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Cadmium levels in maternal blood, placenta, and cord blood in relation to preeclampsia and fetal growth: a case-control study in China.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Prevalence of Exposure to Environmental Metal Mixtures Among Pregnant Women in the United States National Health and Nutrition Examination Survey (NHANES) 1999-2018.Journal of xenobiotics · 2025Article
- Article
- Association of placental manganese levels, maternal gut microbiota, and preeclampsia: a tripartite perspective.Frontiers in microbiology · 2025Article
- First trimester prenatal metal mixtures, vitamins, and hypertensive disorders of pregnancy in the project viva cohort.Environment international · 2024Article
- Article
- The Impact of Serum Uric Acid Levels on Hypertensive Disorders of Pregnancy in Advanced Maternal Age Women: A Retrospective Study from a Single Center in China.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- An exploratory study on the association of multiple metals in serum with preeclampsia.Frontiers in public health · 2024Article
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundToxic metals, such as lead (Pb), cadmium (Cd), arsenic (As), and mercury (Hg), may be associated with a higher risk of gestational hypertension and preeclampsia, whereas manganese (Mn) is an essential metal that may be protective.
objectivesWe estimated the individual, independent, and joint associations of Pb, Cd, As, Hg, and Mn on the risk of developing gestational hypertension and preeclampsia in a cohort of Canadian women.
methodsMetal concentrations were analyzed in first and third trimester maternal blood (
resultsEach doubling of third trimester Pb ( DISCUSSION: Our results confirm that even low blood Pb concentrations are a risk factor for preeclampsia. Women with higher blood As concentrations combined with lower Mn in early pregnancy were more likely to develop gestational hypertension. These pregnancy complications impact maternal and neonatal health. Understanding the contribution of toxic metals and Mn is of public health importance. https://doi.org/10.1289/EHP10825.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.