Evidence map›Paper›PMID 37079809›Full record

ArticleNeuropsychology2023

Misinterpreting cognitive change over multiple timepoints: When practice effects meet age-related decline.

Mark Sanderson-Cimino, Ruohui Chen, Xin M Tu, Jeremy A Elman, Amy J Jak, William S Kremen

Abstract read
In one paragraph

Article in Neuropsychology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Mediators of attachment, frailty, and mild cognitive impairment in older adults.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mark Sanderson-CiminoMemory and Aging Center, University of California San Francisco.ORCID 0000-0002-5872-3186
Ruohui ChenDivision of Biostatistics and Bioinformatics, Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego.
Xin M TuSchool of Medicine, University of California San Diego.
Jeremy A ElmanCenter for Behavior Genetics of Aging, University of California San Diego.
Amy J JakCenter for Behavior Genetics of Aging, University of California San Diego.
William S KremenCenter for Behavior Genetics of Aging, University of California San Diego.

Funding

The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
The VETSA Longitudinal MRI Twin Study of Aging (VETSA MRI 4)R01AG076838 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE, Jeremy A Elman · 2022 to 2026
$8.7M
Genetic Predictors, Transcriptomic Biomarkers, & Neurobiological Signatures of Resilience to Alzheimer's DiseaseR01AG064955 · NIA · UPSTATE MEDICAL UNIVERSITY · PI FENNEMA-NOTESTINE, CHRISTINE, GLATT, STEPHEN J · 2019 to 2023
$3.8M
Clarifying risk and protective factors for dementia with the Interplay of Genes and Environment in Multiple Studies (IGEMS) consortiumR01AG060470 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET, PEDERSEN, NANCY L · 2018 to 2022
$3.6M
Linking genetic subtypes of Alzheimer's disease to biological and cognitive heterogeneityK01AG063805 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A · 2021 to 2024
$516k
Practice Effects in Cognitive Aging: Implications for Biomarkers and Early DiagnosisF31AG064834 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDERSON-CIMINO, MARK · 2020 to 2021
$78k
NIA NIH HHS F31 AG064834NIA NIH HHS K01 AG063805NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG060470NIA NIH HHS R01 AG064955NIA NIH HHS R01 AG076838
6 · The paper itself

Abstract

objectivePractice effects (PE) on cognitive testing have been shown to delay detection of impairment and impede our ability to assess change. When decline over time is expected, as with older adults or progressive diseases, failure to adequately address PEs may lead to inaccurate conclusions because PEs artificially boost scores while pathology- or age-related decline reduces scores. Unlike most methods, a participant-replacement approach can separate pathology- or age-related decline from PEs; however, this approach has only been used across two timepoints. More than two timepoints make it possible to determine if PEs level out after the first follow-up, but it is analytically challenging because individuals may not be assessed at every timepoint.

methodWe examined 1,190 older adults who were cognitively unimpaired (

resultsWithout accounting for PEs, cognitive function appeared to improve or stay the same. However, with the participant-replacement method, we observed significant PEs within both groups at all timepoints. PEs did not uniformly decrease across time; some-specifically on episodic memory measures-continued to increase beyond the first follow-up.

conclusionA replacement method of PE adjustment revealed significant PEs across two follow-ups. As expected in these older adults, accounting for PEs revealed cognitive decline. This, in turn, means earlier detection of cognitive deficits, including progression to MCI, and more accurate characterization of longitudinal change. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Indexed as

Cognition DisordersCognitive DysfunctionMemory, EpisodicAgedCognitionHumansNeuropsychological Tests

Identifiers

PMID37079809
PMCPMC10313772

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.