ArticleCell reports. Medicine2023
Dynamics of AMPA receptors regulate epileptogenesis in patients with epilepsy.
Open access · goldAbstract read
In one paragraph
Article in Cell reports. Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Genome-wide association meta-analyses of drug-resistant epilepsy.EBioMedicine · 2025Pooled it
- Age and sex-dependent alteration in AMPA receptor density in living human brain.European journal of nuclear medicine and molecular imaging · 2026Article
- The dynamics of AMPA receptors underlies the efficacy of ketamine in treatment resistant patients with depression.Molecular psychiatry · 2026Article
- TRIM8 Promotes Epileptiform Activity by Destabilizing the Glucocorticoid Receptor NR3C1 and Enhancing AMPA Receptor Phosphorylation.Biomedicines · 2026Article
- Decorin Attenuates Epileptogenesis and Modulates Hippocampal Synaptic Plasticity via the mTOR Signalling Pathway.Neurochemical research · 2026Article
- Traditional Chinese medicine on epilepsy: focus on N-methyl-D-aspartate receptors and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors.Medical review (2021) · 2025Review
- Article
- Oligomeric alpha-synuclein causes early synaptic dysfunction of the corticostriatal pathway associated with non-motor symptoms.NPJ Parkinson's disease · 2025Article
- First-in-Human Study ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Article
- MicroRNA-138-5p suppresses excitatory synaptic strength at the cerebellar input layer.The Journal of physiology · 2025Article
- AMPA Receptors in Synaptic Plasticity, Memory Function, and Brain Diseases.Cellular and molecular neurobiology · 2025Review
- AMPA receptors in the evolving synapse: structure, function, and disease implications.Frontiers in synaptic neuroscience · 2025Review
- Systemic increase of AMPA receptors associated with cognitive impairment of long COVID.Brain communications · 2025Article
- Chronic reduction of synaptic proteins in the epileptogenic lesion of patients with hippocampal sclerosis.Frontiers in molecular neuroscience · 2025Article
- Molecular Mechanisms of AMPA Receptor Trafficking in the Nervous System.International journal of molecular sciences · 2023Review
- Hebbian and homeostatic synaptic plasticity of AMPA receptors in epileptogenesis.Cell reports. Medicine · 2023Article
- Synaptic alterations and neuronal firing in human epileptic neocortical excitatory networks.Frontiers in synaptic neuroscience · 2023Article
Corrections and comments
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Authors and funding
31 authors at 9 institutions in 1 country.
Tsuyoshi EiroDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan; Department of Psychiatry, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Tomoyuki MiyazakiDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Mai HatanoDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Waki NakajimaDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Tetsu ArisawaDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Yuuki TakadaDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Kimito KimuraDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Akane SanoDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Kotaro NakanoDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Takahiro MiharaDepartment of Health Data Science, Yokohama City University Graduate School of Data Science, Yokohama 236-0004, Japan.
Yutaro TakayamaDepartment of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Naoki IkegayaDepartment of Neurosurgery, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Masaki IwasakiDepartment of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira 187-8551, Japan.
Akitoyo HishimotoDepartment of Psychiatry, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan.
Yoshihiro NodaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-0016, Japan.
Takahiro MiyazakiDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-0016, Japan.
Hiroyuki UchidaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-0016, Japan.
Hideaki TaniDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-0016, Japan.
Nobuhiro NagaiDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-0016, Japan.
Teruki KoizumiDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-0016, Japan.
Shinichiro NakajimaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-0016, Japan.
Masaru MimuraDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo 160-0016, Japan.
Nozomu MatsudaDepartment of Neurology, Fukushima Medical University, Fukushima 960-1295, Japan.
Kazuaki KanaiDepartment of Neurology, Fukushima Medical University, Fukushima 960-1295, Japan.
Kazuhiro TakahashiAdvanced Clinical Research Center, Fukushima Global Medical Science Center, Fukushima Medical University, Fukushima 960-1295, Japan.
Hiroshi ItoAdvanced Clinical Research Center, Fukushima Global Medical Science Center, Fukushima Medical University, Fukushima 960-1295, Japan; Department of Radiology and Nuclear Medicine, Fukushima Medical University, Fukushima 960-1295, Japan.
Yoji HiranoDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan; Department of Psychiatry, Division of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan.
Yuichi KimuraFaculty of Informatics, Cyber Informatics Research Institute, Kindai University, Higashi-Osaka 577-8502, Japan.
Riki MatsumotoDivision of Neurology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Akio IkedaDepartment of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.
Takuya TakahashiDepartment of Physiology, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan; The University of Tokyo, International Research Center for Neurointelligence, Tokyo 113-0033, Japan. Electronic address: takahast@yokohama-cu.ac.jp.
Yokohama City University · JPKeio University · JPFukushima Medical University · JPKindai University · JPKobe University · JPKyoto University · JPNational Center of Neurology and Psychiatry · JPThe University of Tokyo · JPUniversity of Miyazaki · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
The excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) contribute to epileptogenesis. Thirty patients with epilepsy and 31 healthy controls are scanned using positron emission tomography with our recently developed radiotracer for AMPARs, [
Indexed as
EpilepsyReceptors, AMPAHumansNeuronsSeizuresReceptors, AMPAelectroencephalographyepilepsypositron emission tomographyseizuresα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.