ArticleThe journal of headache and pain2023
Neuroanatomical restoration of salience network links reduced headache impact to cognitive function improvement in mild traumatic brain injury with posttraumatic headache.
Article in The journal of headache and pain, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Structural Magnetic Resonance Imaging of Post-Traumatic Headache: A Systematic Review.Current pain and headache reports · 2025Pooled it
- The effects of physical exercise on inflammation-induced maladaptive neuroplasticity in post-traumatic headache.Neuroscience · 2026Review
- The network-based underpinnings of persisting symptoms after concussion: a multimodal neuroimaging meta-analysis.Nature. Mental health · 2025Article
- Exploring cerebral structural and functional abnormalities in a mouse model of post-traumatic headache induced by mild traumatic brain injury.Zoological research · 2024Article
- Inflammation, brain connectivity, and neuromodulation in post-traumatic headache.Brain, behavior, & immunity - health · 2024Review
- Abnormal developmental of structural covariance networks in young adults with heavy cannabis use: a 3-year follow-up study.Translational psychiatry · 2024Article
- Deciphering the brain-gut axis: elucidating the link between cerebral cortex structures and functional gastrointestinal disorders via integrated Mendelian randomization.Frontiers in neuroscience · 2024Article
- Location matters: altered interhemispheric homotopic connectivity in post-stroke dyskinesia.Frontiers in neurology · 2024Article
- Neuroanatomical profile of BMI implicates impulsive delay discounting and general cognitive ability.Obesity (Silver Spring, Md.) · 2023Article
- Being a morning man has causal effects on the cerebral cortex: a Mendelian randomization study.Frontiers in neuroscience · 2023Article
- Two sides of the same coin: distinct neuroanatomical patterns predict crystallized and fluid intelligence in adults.Frontiers in neuroscience · 2023Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundNeuroanatomical alterations have been associated with cognitive deficits in mild traumatic brain injury (MTBI). However, most studies have focused on the abnormal gray matter volume in widespread brain regions using a cross-sectional design in MTBI. This study investigated the neuroanatomical restoration of key regions in salience network and the outcomes in MTBI.
methodsThirty-six MTBI patients with posttraumatic headache (PTH) and 34 matched healthy controls were enrolled in this study. All participants underwent magnetic resonance imaging scans and were assessed with clinical measures during the acute and subacute phases. Surface-based morphometry was conducted to get cortical thickness (CT) and cortical surface area (CSA) of neuroanatomical regions which were defined by the Desikan atlas. Then mixed analysis of variance models were performed to examine CT and CSA restoration in patients from acute to subacute phase related to controls. Finally, mediation effects models were built to explore the relationships between neuroanatomical restoration and symptomatic improvement in patients.
resultsMTBI patients with PTH showed reduced headache impact and improved cognitive function from the acute to subacute phase. Moreover, patients experienced restoration of CT of the left caudal anterior cingulate cortex (ACC) and left insula and cortical surface area of the right superior frontal gyrus from acute to subacute phase. Further mediation analysis found that CT restoration of the ACC and insula mediated the relationship between reduced headache impact and improved cognitive function in patients.
conclusionsThese results showed that neuroanatomical restoration of key regions in salience network correlated reduced headache impact with cognitive function improvement in MTBI with PTH, which further substantiated the vital role of salience network and provided an alternative clinical target for cognitive improvement in MTBI patients with PTH.
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