SynthesisBMC medical genomics2023
Causal effects of modifiable risk factors on kidney stones: a bidirectional mendelian randomization study.
Synthesis in BMC medical genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Risk factors for kidney stone recurrence and early prediction models: a systematic review and meta-analysis.Translational andrology and urology · 2026Article
- The atherogenic index of plasma increases the risk of incident kidney stones: a nested case-control study in Chinese adults.Renal failure · 2025Article
- Older age and low testosterone levels are independently associated with kidney stone prevalence in men: results from a large cross-sectional study.International journal of impotence research · 2025Article
- Article
- Association between Kidney Stones and CKD: A Bidirectional Mendelian Randomization Study.Journal of the American Society of Nephrology : JASN · 2024Article
- Threshold effects between caffeine intake and urine flow rate: a population-based cross-sectional study.International urology and nephrology · 2024Article
- Relationship between the atherogenic index of plasma and the prevalence of kidney stones: insights from a population-based cross-sectional study.Renal failure · 2024Article
- Remnant cholesterol increases the risk of incident kidney stones: a nested case-control study in Chinese adults.Urolithiasis · 2024Article
- Association between remnant cholesterol and risk of kidney stones: a case-control study in Chinese adults.Urolithiasis · 2024Article
- Article
- Association between chinese visceral adiposity index and risk of kidney stones in a health screening population: an ultrasonography based cross-sectional study.BMC nephrology · 2024Article
- Mendelian randomization analysis reveals fresh fruit intake as a protective factor for urolithiasis.Human genomics · 2023Article
- Sleep and circadian rhythm disturbance in kidney stone disease: a narrative review.Frontiers in endocrinology · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreasing epidemiological studies demonstrated that modifiable risk factors affected the risk of kidney stones. We aimed to systemically assess these causal associations using a bidirectional Mendelian randomization study.
methodsWe obtained instrumental variables related to each exposure at the genome-wide significant threshold (P < 5 × 10
resultsAmong 46 risk factors, five were significantly associated with nephrolithiasis risk in the FinnGen consortium, UK Biobank, and meta-analyses collectively. The odds ratios (ORs) (95% confidence intervals [95%CIs]) of kidney stones were 1.21 (1.13, 1.29) per standard deviation (SD) increase in serum calcium, 1.55 (1.01, 2.36) per SD increase in serum 25(OH)D, 1.14 (1.00, 1.29) per SD increase in total triglycerides, 2.38 (1.34, 4.22) per SD increase in fasting insulin, and 0.28 (0.23, 0.35) per unit increase in log OR of urine pH. In addition, genetically predicted serum phosphorus, urinary sodium, tea consumption, and income affected the risk of kidney stones (false discovery rate [FDR] P < 0.05) based on the outcome data from the FinnGen consortium, and the significant associations of education and waist-to-hip ratio with nephrolithiasis risks were found after FDR correction (FDR P < 0.05) based on the outcome data from UK Biobank.
conclusionsOur findings comprehensively provide modifiable risk factors for the prevention of nephrolithiasis. Genome-wide association studies with larger sample sizes are needed to verify these causal associations in the future further.
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