ArticleFrontiers in endocrinology2023
Dyslipidemia and serum cystatin C levels as biomarker of diabetic nephropathy in patients with type 2 diabetes mellitus.
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Association between serum lipid levels and the risk of diabetic nephropathy: a meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Observational
- Association Between Neutrophil-to-HDL Ratio and Full-Spectrum Dysglycemia: Insights from a Large Middle Eastern Population Study.Healthcare (Basel, Switzerland) · 2025Article
- The relationship between serum lipid levels and diabetic nephropathy in patients with primary diabetes.BMC nephrology · 2025Article
- Uric Acid to Platelet Ratio (UAPR) and Its Link to Lipid Abnormalities: Findings from a Large Cohort Study in Saudi Arabia.Journal of clinical medicine · 2025Article
- Dietary Quercetin Intake Is Associated With a Lower Risk of Diabetic Nephropathy in US Adults: Data From NHANES 2007-2008, 2009-2010, and 2017-2018.Food science & nutrition · 2025Article
- Genetic analysis of elevated levels of creatinine and cystatin C biomarkers reveals novel genetic loci associated with kidney function.Human molecular genetics · 2025Article
- The role of advanced glycation end products between thyroid function and diabetic nephropathy and metabolic disorders.Scientific reports · 2025Article
- [High serum cystatin C is an independent risk factor for poor renal prognosis in IgA nephropathy].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Deciphering the Association: Critical HDL-C Levels and Their Impact on the Glycation Gap in People Living with HIV.International journal of molecular sciences · 2025Article
- Relationship between serum cystatin C and diabetic retinopathy in T2DM patients.Frontiers in medicine · 2025Article
- Causal association between cystatin C and diabetic retinopathy: A two-sample Mendelian randomization study.Journal of diabetes investigation · 2024Article
- Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and diabetic kidney disease in patients with diabetes in the United States: a cross-sectional study.Lipids in health and disease · 2024Article
- Integrated machine learning and deep learning for predicting diabetic nephropathy model construction, validation, and interpretability.Endocrine · 2024Article
- CYSTATIN C-A Monitoring Perspective of Chronic Kidney Disease in Patients with Diabetes.International journal of molecular sciences · 2024Review
- A semantic segmentation method to analyze retinal vascular parameters of diabetic nephropathy.Frontiers in medicine · 2024Article
- The relationship between cardiometabolic Index and diabetic kidney disease in people with diabetes.Frontiers in endocrinology · 2024Article
- Amorphophallus campanulatus tuber extract protects diabetic nephropathy in streptozotocin-induced diabetic nephropathy rat model by regulating oxidative stress and TNF-α inflammatory pathway.Acta cirurgica brasileira · 2024Article
- Assessing the causal relationship between gut microbiota and diabetic nephropathy: insights from two-sample Mendelian randomization.Frontiers in endocrinology · 2024Article
Corrections and comments
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Authors and funding
18 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Diabetic nephropathy is a leading cause of end-stage renal disease. The diagnostic markers of nephropathy, including the presence of albuminuria and/or a reduced estimated glomerular filtration rate, are not clinically ideal, and most of them are raised after a significant reduction in renal function. Therefore, it is crucial to seek more sensitive and non-invasive biomarkers for the diagnosis of diabetic nephropathy. Objective of the study: This study aimed to investigate the serum cystatin C levels and dyslipidemia for the detection of diabetic nephropathy in patients with type 2 diabetes mellitus. Methodology: A hospital-based comparative cross-sectional study was conducted from December 2021 to August 2022 in Tikur, Anbessa specialized teaching hospital with a sample size of 140 patients with type2 diabetes mellitus. Socio-demographic data was collected using a structured questionnaire, and 5 mL of blood was collected from each participant following overnight fasting for biochemical analyses. Results: In type 2 diabetes patients with nephropathy, we found significant lipoprotein abnormalities and an increase in serum cystatin C (P < 0.001) compared to those without nephropathy. Serum cystatin C, systolic blood pressure, fasting blood glucose, total cholesterol, triglyceride, low density lipoprotein, very low-density lipoprotein, high density lipoprotein, and duration of diabetes were identified as being significantly associated with diabetic nephropathy (P < 0.05) in multivariable logistic regression analysis. The mean values of total cholesterol levels, triglyceride levels, and high-density lipoprotein cholesterol levels were also found to be significantly higher (P < 0.05) in females as compared to male type-2 diabetic patients. The fasting blood glucose levels and lipid profiles of the participants were found to be significantly associated with serum cystatin C levels. Conclusion: The present study found significant serum cystatin C and lipoprotein abnormalities in T2DM patients with diabetic nephropathy when compared with those without diabetic nephropathy, and these lipoprotein abnormalities were significantly associated with serum cystatin C levels.
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