Evidence map›Paper›PMID 37084008›Full record

ReviewCurrent allergy and asthma reports2023

Genetic and Molecular Contributors in Eosinophilic Esophagitis.

Hiroki Sato, Kasumi Osonoi, Colby S Sharlin, Tetsuo Shoda

Open access · greenAbstract readReview
In one paragraph

Review in Current allergy and asthma reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Introducing ICAM1 as a possible drug target in treatment of eosinophilic esophagitis.Gastroenterology and hepatology from bed to bench · 2025
    Article
  4. Eosinophilic esophagitis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2024
    Review
  5. Review
  6. Article
  7. Development and dysfunction of structural cells in eosinophilic esophagitis.The Journal of allergy and clinical immunology · 2024
    Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hiroki SatoDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Kasumi OsonoiDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Colby S SharlinDivision of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Tetsuo ShodaDivision of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Tetsuo.Shoda@cchmc.org.ORCID 0000-0001-8337-5438
Cincinnati Children's Hospital Medical Center · US

Funding

PEDIATRIC GASTROENTEROLOGY AND NUTRITION TRAINING GRANTT32DK007727 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Phillip P Minar · 1995 to 2026
$11.3M
Combinatory Effects of Genetic Variants in Eosinophilic EsophagitisR00AI158660 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI SHODA, TETSUO · 2023 to 2024
$498k
Combinatory Effects of Genetic Variants in Eosinophilic EsophagitisK99AI158660 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI SHODA, TETSUO · 2021 to 2022
$261k
NIAID NIH HHS K99 AI158660NIAID NIH HHS R00 AI158660NIDDK NIH HHS T32 DK007727
6 · The paper itself

Abstract

purpose of reviewEosinophilic esophagitis (EoE) is an allergic inflammatory esophageal disorder with a complex underlying genetic and molecular etiology. The interest of the scientific community in EoE has grown considerably over the past three decades, and the understanding of the genetic and molecular mechanisms involved in this disease has greatly increased. RECENT

findingsIn this article, we aim to provide both historic aspects and updates on the recent genetic and molecular advances in the understanding of EoE. Although EoE is a relatively newly described disorder, much progress has been made toward identifying the genetic and molecular factors contributing to the disease pathogenesis by a variety of approaches with next-generation sequencing technologies, including genome-wide association study, whole exome sequencing, and bulk and single-cell RNA sequencing. This review highlights the multifaceted impacts of various findings that have shaped the current molecular and genetic landscape of EoE, providing insights that facilitate further understanding of the disease process.

Indexed as

Eosinophilic EsophagitisGenome-Wide Association StudyHumansInflammationEosinophilic esophagitis diagnostic panelEosinophilic gastrointestinal diseaseGenome-wide association studySingle-cell RNA sequencingTranscriptomeWhole exome sequencing

Identifiers

PMID37084008
PMCPMC11136533
OpenAlexW4366603566

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.