ArticleBMJ open diabetes research & care2023
Effect of the interaction between advanced maternal age and pre-pregnancy BMI on pre-eclampsia and GDM in Central China.
Article in BMJ open diabetes research & care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Association of CDKAL1 gene polymorphisms variations with gestational diabetes mellitus risk in women: A case-control study and meta-analysis.BMC endocrine disorders · 2025Pooled it
- Global prevalence of preeclampsia, eclampsia, and HELLP syndrome: a systematic review and meta-analysis.Frontiers in reproductive health · 2025Pooled it
- Correlation Between Placental Hormones and Placental Elasticity and the Relationship Between These Parameters and Pregnancy Outcomes.Journal of clinical ultrasound : JCU · 2026Article
- Association between high maternal haemoglobin levels in the first trimester and gestational diabetes mellitus: a prospective birth cohort study.Journal of global health · 2026Article
- Potential for primary prevention of low birth weight in pregnancies with and without gestational diabetes mellitus: a prospective cohort study in Central China.BMC pregnancy and childbirth · 2026Article
- Severe maternal morbidity in patients of advanced maternal age with and without metabolic syndrome.Archives of gynecology and obstetrics · 2026Article
- Phospholipid transfer protein: The link between lipid metabolism and inflammation in healthy pregnancy and pregnancy with cardiometabolic complications.Journal of medical biochemistry · 2026Article
- Opportunities and Challenges for Precision Nutrition in Gestational Obesity Management.Current obesity reports · 2026Review
- Associations of the Mediterranean diet during pregnancy with impaired glucose tolerance and gestational diabetes: A national prospective cohort study in Lebanon.European journal of clinical nutrition · 2026Article
- Information Needs for Artificial Intelligence Chatbot on Prenatal Care Among Women of Advanced Maternal Age: A Thematic Analysis.Nursing open · 2026Article
- Article
- Maternal Prepregnancy Overweight: Associations With Maternal and Offspring Weight 4-7 Years Postpartum.Journal of diabetes research · 2026Article
- Distinct modifiable risk factors and preventable burdens of preterm birth: a risk-stratified analysis of pregnancies with and without gestational diabetes mellitus.Frontiers in pediatrics · 2026Article
- Effects of pre-pregnancy dairy consumption on gestational diabetes mellitus: a prospective cohort study among Chinese women.Frontiers in nutrition · 2026Article
- The association between early pregnancy maternal lipid indicators with gestational diabetes mellitus and pre-eclampsia.Journal of lipid research · 2025Article
- Unveiling the risks and outcomes of preeclampsia: a case-control study in the UAE.BMC pregnancy and childbirth · 2025Article
- Observational
- Polygenic Risk Score Associated with Gestational Diabetes Mellitus in an AmericanIndian Population.Journal of personalized medicine · 2025Article
- The study of the relationship between physical activity and gestational diabetes mellitus in the second trimester of pregnancy: a dose-response analysis with the restricted cubic spline model.BMC pregnancy and childbirth · 2025Article
- Barriers and facilitators to attending postpartum diabetes screening among women with previous gestational diabetes in China: A qualitative analysis.Diabetic medicine : a journal of the British Diabetic Association · 2025Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTo investigate the independent and combined effects of advanced maternal age and pre-pregnancy body mass index (BMI) on the risk of pre-eclampsia and gestational diabetes mellitus (GDM). RESEARCH DESIGN AND
methodsLogistic regression models were used to estimate the OR and 95% CIs of pre-eclampsia and GDM with advanced maternal age and pre-pregnancy BMI, respectively, and the interaction between advanced maternal age and pre-pregnancy BMI. We also used causal mediation analysis to assess the mediating role of pre-pregnancy BMI on maternal age-pre-eclampsia/GDM associations.
resultsIn this study, 788 cases (2.31%) were diagnosed with pre-eclampsia and 5430 cases (15.92%) were diagnosed with GDM. We found that advanced maternal age was associated with a higher risk for pre-eclampsia and GDM, with adjusted ORs (aORs) of 1.74 (95% CI 1.49-2.05) and 1.76 (95% CI 1.65-1.89) after adjusting for potential confounders, respectively. In addition, maternal pre-pregnancy overweight/obesity was associated with the risk of pre-eclampsia and GDM, with the corresponding aORs of 3.64 (95% CI 3.12-4.24) and 1.71 (95% CI 1.60-1.85), respectively. We also observed the interaction between maternal age and pre-pregnancy BMI for the risk of pre-eclampsia/GDM (all p for interaction <0.001). In the mediating effect analysis, we found that maternal pre-pregnancy BMI mediated the associations between maternal age and the development of pre-eclampsia and GDM.
conclusionsAdvanced maternal age and pre-pregnancy BMI were respectively associated with the risk of pre-eclampsia/GDM, and there was an interaction between the two risk factors. In addition, we found that pre-pregnancy BMI served as a mediator of the association between advanced maternal age and the risk of pre-eclampsia/GDM, providing an essential target for the prevention of maternal overweight/obesity.
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