Evidence map›Paper›PMID 37087182›Full record

ArticleLife sciences in space research2023

Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model.

Ashley S Nemec-Bakk, Vijayalakshmi Sridharan, John W Seawright, Gregory A Nelson, Maohua Cao, Preeti Singh, Amrita K Cheema, Bhaldev Singh, Yaoxiang Li, Igor Koturbash and 8 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life sciences in space research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Biological effects of high-LET irradiation on the circulatory system.International journal of radiation biology · 2025
    Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 1 country.

Ashley S Nemec-BakkDivision of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address: ANemecbakk@uams.edu.
Vijayalakshmi SridharanDivision of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
John W SeawrightMcLennan Community College, Waco, TX, USA.
Gregory A NelsonDepartments of Basic Sciences and Radiation Medicine, Loma Linda University, Loma Linda, CA, USA.
Maohua CaoCollege of Dentistry, Texas A&M, Dallas, TX, USA.
Preeti SinghRite Aid Pharmacy, Bayonne, NJ, USA.
Amrita K CheemaDepartment of Oncology, Georgetown University Medical Center, Washington, DC, USA.
Bhaldev SinghDepartment of Oncology, Georgetown University Medical Center, Washington, DC, USA.
Yaoxiang LiDepartment of Oncology, Georgetown University Medical Center, Washington, DC, USA.
Igor KoturbashDepartment of Environmental Health Sciences, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Isabelle R MiousseDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Laura E EwingNatural State Laboratories and Natural State Genomics, North Little Rock, AR, USA.
Charles M SkinnerDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Reid D LandesDepartment of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
John D LoweryDepartment of Laboratory Animal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Xiao-Wen MaoDepartments of Basic Sciences and Radiation Medicine, Loma Linda University, Loma Linda, CA, USA.
Sharda P SinghDepartment of Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Marjan BoermaDivision of Radiation Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
University of Arkansas for Medical Sciences · USGeorgetown University · USLoma Linda University · USMcLennan Community College · USRite Aid (United States) · USTexas Tech University · USUniversity of Arkansas Medical Center · US

Funding

NIGMS NIH HHS P20 GM109005
6 · The paper itself

Abstract

purposeAstronauts on missions beyond low Earth orbit will be exposed to galactic cosmic radiation, and there is concern about potential adverse cardiovascular effects. Most of the research to identify cardiovascular risk of space radiation has been performed in rodent models. To aid in the translation of research results to humans, the current study identified long-term effects of high-energy charged particle irradiation on cardiovascular function and structure in a larger non-rodent animal model. MATERIALS AND

methodsAt the age of 12 months, male New Zealand white rabbits were exposed to whole-body protons (250 MeV) or oxygen ions (

resultsA small but significant decrease in the percentage of circulating lymphocytes and an increase in neutrophil percentage was seen 12 months after 0.5 Gy protons, while

conclusionLow dose charged particle irradiation caused mild long-term changes in inflammatory markers, cardiac function, and structure in the rabbit heart, in line with previous studies in mouse and rat models.

Indexed as

Cosmic RadiationProtonsAnimalsDose-Response Relationship, RadiationHeartHumansInfantIonsMaleMiceOxygenRabbitsRatsIonsOxygenProtonsCardiovascular systemDegenerative tissue effectsOxygen ionsProtonsRabbit modelSpace radiation

Identifiers

PMID37087182
PMCPMC10122719
OpenAlexW4361274418

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.