Evidence map›Paper›PMID 37087486›Full record

ArticleArchives of toxicology2023

Next generation risk assessment of human exposure to estrogens using safe comparator compound values based on in vitro bioactivity assays.

Tessa C A van Tongeren, Si Wang, Paul L Carmichael, Ivonne M C M Rietjens, Hequn Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Tessa C A van TongerenDivision of Toxicology, Wageningen University and Research, 6700 EA, Wageningen, The Netherlands. tessa.vantongeren@wur.nl.ORCID http://orcid.org/0000-0002-6068-485X
Si WangDivision of Toxicology, Wageningen University and Research, 6700 EA, Wageningen, The Netherlands.
Paul L CarmichaelUnilever Safety and Environmental Assurance Centre, Sharnbrook, Bedfordshire, MK44 1LQ, UK.
Ivonne M C M RietjensDivision of Toxicology, Wageningen University and Research, 6700 EA, Wageningen, The Netherlands.
Hequn LiUnilever Safety and Environmental Assurance Centre, Sharnbrook, Bedfordshire, MK44 1LQ, UK.
Wageningen University & Research · NLUnilever (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In next generation risk assessment (NGRA), the Dietary Comparator Ratio (DCR) can be used to assess the safety of chemical exposures to humans in a 3R compliant approach. The DCR compares the Exposure Activity Ratio (EAR) for exposure to a compound of interest (EAR

Indexed as

EstrogensReceptors, EstrogenCell Line, TumorGenisteinHumansRisk AssessmentEstrogensGenisteinReceptors, Estrogen3R compliant methodDietary ComparatorEstrogen receptorIn vitro/in silico approachesRisk assessment

Identifiers

PMID37087486
PMCPMC10182946
OpenAlexW4366768220

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.