Evidence map›Paper›PMID 37089589›Full record

ArticleFrontiers in medicine2023

A feasibility study for quantitative assessment of cerebrovascular malformations using flutriciclamide ([

Sally Ji Who Kim, Janine M Lupo, Yicheng Chen, Miguel H Pampaloni, Henry F VanBrocklin, Jared Narvid, Helen Kim, Youngho Seo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sally Ji Who KimDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
Janine M LupoDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
Yicheng ChenDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
Miguel H PampaloniDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
Henry F VanBrocklinDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
Jared NarvidDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.
Helen KimDepartment of Anesthesia and Perioperative Care, Center for Cerebrovascular Research, University of California, San Francisco, San Francisco, CA, United States.
Youngho SeoDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.

Funding

VCRC Administration UnitU54NS065705 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KIM, HELEN · 2009 to 2023
$20.8M
NINDS NIH HHS U54 NS065705
6 · The paper itself

Abstract

Aim: Neuroinflammation plays a key role in both the pathogenesis and the progression of cerebral cavernous malformations (CCM). Flutriciclamide ([ Materials and methods: Five patients with CCM and six controls underwent a 60 or 90 min continuous PET/MRI scan following 315 ± 68.9 MBq flutriciclamide administration. Standardized uptake value (SUV) and standardized uptake value ratio (SUVr) were obtained using the striatum as a pseudo-reference. Quantitative susceptibility maps (QSM) were used to define the location of the vascular malformation and calculate the amount of iron deposition in each lesion. Results: Increased flutriciclamide uptake was observed in all CCM lesions. The temporal pole demonstrated the highest radiotracer uptake; the paracentral lobule, cuneus and hippocampus exhibited moderate uptake; while the striatum had the lowest uptake, with average SUVs of 0.66, 0.55, 0.63, 0.55, and 0.33 for patient with CCM and 0.57, 0.50, 0.48, 0.42, and 0.32 for controls, respectively. Regional SUVr showed similar trends. The average SUV and QSM values in CCM lesions were 0.58 ± 0.23 g/ml and 0.30 ± 0.10 ppm. SUVs and QSM were positively correlated in CCM lesions ( Conclusion: The distribution of flutriciclamide ([

Indexed as

CCMflutriciclamideGE-180neuroinflammationPET/MRIquantitative susceptibility mapping (QSM)TSPOvascular malformation

Identifiers

PMID37089589
PMCPMC10116613

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.