Evidence map›Paper›PMID 37091234›Full record

ArticleiScience2023

β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signaling.

Le May Thai, Liam O'Reilly, Saskia Reibe-Pal, Nancy Sue, Holly Holliday, Lewin Small, Carsten Schmitz-Peiffer, Rama Dhenni, Vicky Wang-Wei Tsai, Nicholas Norris and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Islet Tissue Macrophages in Immunity Homeostasis and Type 1 Diabetes.Clinical reviews in allergy & immunology · 2025
    Review
  9. Article
  10. Review
  11. Article
  12. Protective Role of MerTK in Diabetic Peripheral Neuropathy via Inhibition of the NF-κB Signaling Pathway.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2024
    Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 5 institutions in 1 country.

Le May ThaiGarvan Institute of Medical Research, Sydney, NSW, Australia.
Liam O'ReillyGarvan Institute of Medical Research, Sydney, NSW, Australia.
Saskia Reibe-PalGarvan Institute of Medical Research, Sydney, NSW, Australia.
Nancy SueGarvan Institute of Medical Research, Sydney, NSW, Australia.
Holly HollidayGarvan Institute of Medical Research, Sydney, NSW, Australia.
Lewin SmallGarvan Institute of Medical Research, Sydney, NSW, Australia.
Carsten Schmitz-PeifferGarvan Institute of Medical Research, Sydney, NSW, Australia.
Rama DhenniGarvan Institute of Medical Research, Sydney, NSW, Australia.
Vicky Wang-Wei TsaiCentre for Applied Medical Research, Sydney, NSW, Australia.
Nicholas NorrisSchool of Medical Sciences, Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
Belinda YauCentre for Applied Medical Research, Sydney, NSW, Australia.
Xuan ZhangGarvan Institute of Medical Research, Sydney, NSW, Australia.
Kailun LeeGarvan Institute of Medical Research, Sydney, NSW, Australia.
Chenxu YanGarvan Institute of Medical Research, Sydney, NSW, Australia.
Yan-Chuan ShiGarvan Institute of Medical Research, Sydney, NSW, Australia.
Melkam A KebedeSchool of Medical Sciences, Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia.
Robert BrinkGarvan Institute of Medical Research, Sydney, NSW, Australia.
Gregory J CooneyGarvan Institute of Medical Research, Sydney, NSW, Australia.
Katharine M IrvineMater Research Institute-University of Queensland, Brisbane, QLD, Australia.
Samuel N BreitSt Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, NSW, Australia.
Tri G PhanGarvan Institute of Medical Research, Sydney, NSW, Australia.
Alexander SwarbrickGarvan Institute of Medical Research, Sydney, NSW, Australia.
Trevor J BidenGarvan Institute of Medical Research, Sydney, NSW, Australia.
Garvan Institute of Medical Research · AUThe University of Sydney · AUWestmead Institute for Medical Research · AUThe University of Queensland · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have exploited islet-associated macrophages (IAMs) as a model of resident macrophage function, focusing on more physiological conditions than the commonly used extremes of M1 (inflammation) versus M2 (tissue remodeling) polarization. Under steady state, murine IAMs are metabolically poised between aerobic glycolysis and oxidative phosphorylation, and thereby exert a brake on glucose-stimulated insulin secretion (GSIS). This is underpinned by epigenetic remodeling via the metabolically regulated histone demethylase Kdm5a. Conversely, GSIS is enhanced by engaging Axl receptors on IAMs, or by augmenting their oxidation of glucose. Following high-fat feeding, efferocytosis is stimulated in IAMs in conjunction with Mertk and TGFβ receptor signaling. This impairs GSIS and potentially contributes to β-cell failure in pre-diabetes. Thus, IAMs serve as relays in many more settings than currently appreciated, fine-tuning insulin secretion in response to dynamic changes in the external environment. Intervening in this nexus might represent a means of preserving β-cell function during metabolic disease.

Indexed as

Cell biologyImmunologyPhysiology

Identifiers

PMID37091234
PMCPMC10113792
OpenAlexW4353047563

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.