ArticleEuropean radiology2023
Diffusion prepared pseudo-continuous arterial spin labeling reveals blood-brain barrier dysfunction in patients with CADASIL.
Article in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- MRI markers of brain fluid dynamics link reduced blood-brain barrier water exchange rate to disease severity in CADASIL.European stroke journal · 2026Article
- DCE-MRI study on regional and Fazekas-stratified heterogeneity of blood-brain barrier leakage in white matter hyperintensities and related risk factors.Quantitative imaging in medicine and surgery · 2026Article
- Gadolinium- and water-based blood-brain barrier dysfunction measures in patients with sporadic small vessel disease.Cerebral circulation - cognition and behavior · 2026Article
- Arterial spin labeling MRI in CADASIL: Implications for cerebral small vessel disease and therapeutic trials.Cerebral circulation - cognition and behavior · 2026Review
- Persistent vessel wall enhancement and progression of cerebral microbleeds in CADASIL: a case report.Frontiers in radiology · 2026Article
- Imaging markers of neuroinflammation in aging and Alzheimer's disease and related dementia: A comprehensive review.Neuroscience and biobehavioral reviews · 2025Review
- The pathogenesis of cerebral small vessel disease and vascular cognitive impairment.Physiological reviews · 2025Review
- Diffusion-weighted arterial spin labeling MRI to investigate mannitol-induced blood brain barrier disruption.Magnetic resonance imaging · 2025Article
- Decreased water exchange rate across the blood-brain barrier throughout the Alzheimer's disease continuum: Evidence from Chinese data.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Article
- Heterogeneous blood-brain barrier dysfunction in cerebral small vessel diseases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Age-Related Decline in Blood-Brain Barrier Function is More Pronounced in Males than Females in Parietal and Temporal Regions.bioRxiv : the preprint server for biology · 2024Article
- Alterations of the blood-brain barrier during aging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Review
- The impact of mechanical thrombectomy on the blood-brain barrier in patients with acute ischemic stroke: A non-contrast MR imaging study using DP-pCASL and NODDI.NeuroImage. Clinical · 2024Article
- Cerebral Perfusion and Blood-Brain Barrier Changes After Cranioplasty: A Diffusion-Prepared Arterial Spin Labeling Study.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 4 countries.
Funding
Abstract
objectivesDiffusion prepared pseudo-continuous arterial spin labeling (DP-pCASL) is a newly proposed MRI method to noninvasively measure the function of the blood-brain barrier (BBB). We aim to investigate whether the water exchange rate across the BBB, estimated with DP-pCASL, is changed in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), and to analyze the association between the BBB water exchange rate and MRI/clinical features of these patients.
methodsForty-one patients with CADASIL and thirty-six age- and sex-matched controls were scanned with DP-pCASL MRI to estimate the BBB water exchange rate (k
resultsCompared with that in the controls, k
conclusionsThis study found that the BBB water exchange rate was decreased in patients with CADASIL. The decreased BBB water exchange rate was associated with an increased MRI lesion burden and functional dependence of the patients, suggesting the involvement of BBB dysfunction in the pathogenesis of CADASIL. CLINICAL RELEVANCE STATEMENT: DP-pCASL reveals BBB dysfunction in patients with CADASIL. The decreased BBB water exchange rate is associated with MRI lesion burden and functional dependence, indicating the potential of DP-pCASL as an evaluation method for disease severity. KEY POINTS: • DP-pCASL reveals blood-brain barrier dysfunction in patients with CADASIL. • Decreased BBB water exchange rate, an indicator of BBB dysfunction detected by DP-pCASL, was associated with MRI/clinical features of patients with CADASIL. • DP-pCASL can be used as an evaluation method to assess the severity of disease in patients with CADASIL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.