Evidence map›Paper›PMID 37100378›Full record

ArticleLife sciences2023

Cadmium exposure induces a sex-dependent decline in left ventricular cardiac function.

Michael L Fitch, Raihan Kabir, Obialunanma V Ebenebe, Nicole Taube, Haley Garbus, Prithvi Sinha, Nadan Wang, Sumita Mishra, Brian L Lin, Grace K Muller and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Gestational arsenite exposure alters maternal postpartum heart size and induces CaAmerican journal of physiology. Heart and circulatory physiology · 2025
    Article
  5. A murine model ofMicrobiology spectrum · 2025
    Article
  6. Review
  7. A murine model ofbioRxiv : the preprint server for biology · 2024
    Article
  8. Review
  9. Contaminant Metals and Cardiovascular Health.Journal of cardiovascular development and disease · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Michael L FitchDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America. Electronic address: mfitch@luc.edu.
Raihan KabirDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America. Electronic address: rkabir1@jhu.edu.
Obialunanma V EbenebeDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America. Electronic address: oebeneb1@jhmi.edu.
Nicole TaubeDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America. Electronic address: ntaube1@jhmi.edu.
Haley GarbusDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America. Electronic address: hgarbus1@jhmi.edu.
Prithvi SinhaDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America. Electronic address: prsinha@pennmedicine.upenn.edu.
Nadan WangDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America. Electronic address: nwang31@jhmi.edu.
Sumita MishraDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America. Electronic address: smishr12@jh.edu.
Brian L LinDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America. Electronic address: blin29@jhmi.edu.
Grace K MullerDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America; Department of Cell and Molecular Physiology, Loyola University Stritch School of Medicine, Maywood, IL, United States of America. Electronic address: gmuller@luc.edu.
Mark J KohrDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America. Electronic address: mkohr1@jhu.edu.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

Traning Program in Environmental Health SciencesT32ES007141 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI Marsha Wills-Karp · 1985 to 2026
$22.2M
S-nitrosation in cell survival and cell deathR01HL136496 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KOHR, MARK JEFFREY · 2018 to 2022
$2.0M
Basic and Clinical Research Training for Medical StudentsT35HL120835 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI ZELEZNIK-LE, NANCY J · 2015 to 2024
$628k
Role of formaldehyde, formate and one-carbon metabolism in the female heartR21HL157800 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI KOHR, MARK JEFFREY · 2021 to 2022
$450k
TRPC6 inhibition therapy to rescue cardiac muscle dysfunction in muscular dystrophyK99HL155840 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI LIN, BRIAN LEEI · 2022 to 2023
$261k
Sex Differences in Endogenous Formaldehyde Production and One-Carbon Metabolism: Potential Links to CardioprotectionF31HL165820 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI GARBUS, HALEY CAITLIN · 2022 to 2023
$74k
NHLBI NIH HHS F31 HL165820NHLBI NIH HHS K99 HL155840NHLBI NIH HHS R01 HL136496NHLBI NIH HHS R21 HL157800NHLBI NIH HHS T35 HL120835NIEHS NIH HHS T32 ES007141
6 · The paper itself

Abstract

aimsCadmium exposure is a worldwide problem that has been linked to the development of cardiovascular disease. This study aimed to elucidate mechanistic details of chronic cadmium exposure on the structure and function of the heart. MAIN

methodsMale and female mice were exposed to cadmium chloride (CdCl KEY

findingsMales exhibited a significant reduction in left ventricular ejection fraction and fractional shortening with CdCl SIGNIFICANCE: The findings of our novel study provide important insight into how cadmium exposure may act as a sex-specific driver of cardiovascular disease, and further underscore the importance of reducing human exposure to cadmium.

Indexed as

Cardiovascular DiseasesVentricular Function, LeftAnimalsCadmiumCalciumFemaleHumansMaleMiceMyocytes, CardiacSarcoplasmic Reticulum Calcium-Transporting ATPasesStroke VolumeCadmiumCalciumSarcoplasmic Reticulum Calcium-Transporting ATPasesCadmiumCardiovascular diseaseHeart functionSex-dependent

Identifiers

PMID37100378
PMCPMC10246466
OpenAlexW4366817924

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.