ArticleAging clinical and experimental research2023
Physical activity plays a crucial role in multidomain intervention for frailty prevention.
Article in Aging clinical and experimental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06767410 (A Multi-domain Intervention to Constrast Cognitive Decline in Healthy Aging), which is not on this map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multi-domain Intervention to Constrast Cognitive Decline in Healthy Aging
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Physical activity and exercise for the prevention and management of mild cognitive impairment and dementia: a collaborative international guideline.European geriatric medicine · 2023Guideline
- Pain neuroscience education with physical activity improves physical and psychological outcomes in older women with chronic low back pain.Scientific reports · 2025Trial
- Impact of a nurse-led multidomain intervention on intrinsic capacity among community-dwelling older adults in China: a cluster randomized trial.BMC public health · 2025Trial
- Association of frailty with dementia and the impact of frailty on antihypertensive treatment protection against dementia in older hypertensive adults.Age and ageing · 2026Article
- Empowering the vulnerable in internal medicine: a narrative review on physical exercise as a tool to tackle frailty.Internal and emergency medicine · 2025Review
- What Do We Know About Prevention of Frailty in Women?American journal of lifestyle medicine · 2025Review
- Frailty and physical activity: are all physical activity variables equal?The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Does engagement in healthy ageing differ according to gender? Community-based cross-sectional study.Journal of health, population, and nutrition · 2025Article
- The effect of frailty on the relationship between cognition and depression symptoms in older people. A differential analysis by European regions.GeroScience · 2025Article
- Aging, longevity, and healthy aging: the public health approach.Aging clinical and experimental research · 2025Review
- Examining the Relationship Between Urinary Incontinence and Women's Physical Activity Engagement: Barriers and Disclosure Patterns.Healthcare (Basel, Switzerland) · 2025Article
- Musculoskeletal diseases, infections and vaccines: state of the art, research perspectives and educational needs.Aging clinical and experimental research · 2025Review
- Explaining the Association Between Number of Teeth and Frailty in Older Chinese Adults: The Chain Mediating Effect of Nutritional Status and Cognitive Function.International journal of nursing practice · 2025Article
- Long-Term Impact of Physical Activity on Mortality in Adults With Multimorbidity: A 12-Year Cohort Longitudinal Study From the Survey on Health, Ageing and Retirement in Europe.Journal of cachexia, sarcopenia and muscle · 2025Article
- Observational
- Coexisting frailty and depression associated with low physical activity and quality of life in Saudi community-dwelling older adults: a cross-sectional study.Frontiers in public health · 2025Article
- Developing a theory-based intervention to enhance physical activity in older adults with atrial fibrillation and frailty: a behavior change wheel approach.Frontiers in public health · 2025Article
- Comparative Analysis of Physical Fitness in Aquatic and Terrestrial Environments Among Elderly Women.International journal of environmental research and public health · 2024Article
- The Importance of Multidimensional Frailty in Clinical Practice.Journal of clinical medicine · 2024Article
- The Impact of Frailty on Patients With AF and HFrEF Undergoing Catheter Ablation: A Nationwide Population Study.JACC. Advances · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsTaiwan is one of the most rapidly aging countries worldwide. Both physical activity and frailty affect older adults, and multidomain interventions prevent frailty. This study investigated the associations between physical activity, frailty, and the effects of multidomain intervention.
methodsThis study enrolled individuals aged 65 years or older. The physical activity level was assessed using the Physical Activity Scale for the Elderly (PASE). Enrollees participated in a multidomain intervention program that consisted of twelve 120-min sessions administered over a 12-week period that included health education, cognitive training, and exercise programs. The effects of the intervention were evaluated using the instrumental activities of daily living scale (IADL), Mini Nutritional Assessment short form (MNA-SF), five-item Geriatric Depression Scale (GDS-5), Mini-Mental State Examination (MMSE), timed up and go test (TUGT), and Fried's frailty phenotype.
resultsIn total, 106 older adults (aged 65-96 years) were enrolled in this study. The mean age was 77.47 ± 7.19 years, and 70.8% of participants were women. PASE scores were significantly lower among participants who were of older age, frail, and had a history of falls in the last 12 months. Frailty could be improved by multidomain interventions and was significantly positively correlated with depression, and negatively correlated with physical activity, mobility, cognition and daily living skills. Moreover, daily living skills were significantly positively correlated with cognition, mobility and physical activity, and negatively correlated with age, sex, and frailty. However, multidomain interventions did not affect daily living skills suggesting daily living skills may need to be maintained from a young age. Finally, results from multiple regressions suggest that physical activity, mobility and depression may be predictors of frailty.
conclusionsPhysical activity has an important role in frailty, may be a predictor of frailty, and strongly contributes to reducing frailty through multidomain intervention. Policies that encourage healthy aging should focus on increasing physical activity, maintaining basic daily living skills and reducing frailty.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.