Evidence map›Paper›PMID 37101794›Full record

ArticlePeerJ2023

PAIP1 regulates expression of immune and inflammatory response associated genes at transcript level in liver cancer cell.

Jianfeng Zheng, Weiwei Fan, Xiaoyu Zhang, Weili Quan, Yunfei Wu, Mengni Shu, Moyang Chen, Ming Liang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Jianfeng ZhengDepartment of Laboratory Medicine, Baoan Central Hospital of Shenzhen, The Fifth Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.
Weiwei FanDepartment of Infectious Medicine, Heilongjiang Provincial Hospital, Harbin, Heilongjiang, China.
Xiaoyu ZhangFirst Department of Infection, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Weili QuanCenter for Genome Analysis, ABLife Inc., Wuhan, Hubei, China.
Yunfei WuCenter for Genome Analysis, ABLife Inc., Wuhan, Hubei, China.
Mengni ShuFirst Department of Infection, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Moyang ChenFirst Department of Infection, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Ming LiangFirst Department of Infection, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Second Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CNHeilongjiang Provincial Hospital · CNShenzhen University · CNWuhan Institute of Bioengineering · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Poly(A) binding protein interacting protein 1 (PAIP1) is a translation regulator and also regulate the decay of mRNA. PAIP1 has also been reported to be a marker of increased invasive potential of liver cancer. However, the roles and underlying molecular mechanism of PAIP1 in liver cancer is still unclear. Here, cell viability and the gene expression profile of liver cancer line HepG2 transfected with PAIP1 siRNA was compared with cells transfected with non-targeting control siRNA. The results showed that PAIP1 knockdown inhibited cell viability, and extensively affects expression of 893 genes at transcriptional level in HepG2 cells. Gene function analysis showed that a large number of PAIP1 up-regulated genes were enriched in term of DNA-dependent transcription and the down-regulated genes were enriched in some pathways including immune response and inflammatory response. qPCR confirmed that PAIP1 knockdown positively regulated the expression of selected immune and inflammatory factor genes in HepG2 cells. Expression analysis of TCGA revealed that PAIP1 had positive correlations with two immune associated genes IL1R2 and PTAFR in liver tumor tissue. Taken together, our results demonstrated that PAIP1 was not only a translation regulator, but also a transcription regulator in liver cancer. Moreover, PAIP1 could function as a regulatory factor of immune and inflammatory genes in liver cancer. Thus, our study provides important cues for further study on the regulatory mechanism of PAIP1 in liver cancer.

Indexed as

Liver NeoplasmsCell LineHumansPeptide Initiation FactorsRNA-Binding ProteinsRNA, MessengerRNA, Small InterferingPeptide Initiation FactorsRNA-Binding ProteinsRNA, MessengerRNA, Small InterferingGene expressionImmune responseInflammatory responseLiver cancerPAIP1

Identifiers

PMID37101794
PMCPMC10124545
OpenAlexW4366687532

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.