Evidence map›Paper›PMID 37101797›Full record

ArticleMedComm2023

Genetic inhibition of glutamate allosteric potentiation of GABA

Yehong Du, Junjie Li, Maoju Wang, Qiuyun Tian, Yayan Pang, Ya Wen, Dongchuan Wu, Yu Tian Wang, Zhifang Dong

Open access · goldAbstract read
In one paragraph

Article in MedComm, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Yehong DuGrowth, Development, and Mental Health of Children and Adolescence Center Pediatric Research Institute Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders China International Science and Technology Cooperation Base of Child Development and Critical Disorders Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders Children's Hospital of Chongqing Medical University Chongqing China.
Junjie LiGrowth, Development, and Mental Health of Children and Adolescence Center Pediatric Research Institute Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders China International Science and Technology Cooperation Base of Child Development and Critical Disorders Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders Children's Hospital of Chongqing Medical University Chongqing China.
Maoju WangGrowth, Development, and Mental Health of Children and Adolescence Center Pediatric Research Institute Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders China International Science and Technology Cooperation Base of Child Development and Critical Disorders Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders Children's Hospital of Chongqing Medical University Chongqing China.
Qiuyun TianGrowth, Development, and Mental Health of Children and Adolescence Center Pediatric Research Institute Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders China International Science and Technology Cooperation Base of Child Development and Critical Disorders Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders Children's Hospital of Chongqing Medical University Chongqing China.
Yayan PangGrowth, Development, and Mental Health of Children and Adolescence Center Pediatric Research Institute Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders China International Science and Technology Cooperation Base of Child Development and Critical Disorders Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders Children's Hospital of Chongqing Medical University Chongqing China.
Ya WenBrain Research Centre and Department of Medicine Vancouver Coastal Health Research Institute University of British Columbia Vancouver British Columbia Canada.
Dongchuan WuTranslational Medicine Research Center China Medical University Hospital Graduate Institutes of Biomedical Sciences Taichung China.
Yu Tian WangBrain Research Centre and Department of Medicine Vancouver Coastal Health Research Institute University of British Columbia Vancouver British Columbia Canada.
Zhifang DongGrowth, Development, and Mental Health of Children and Adolescence Center Pediatric Research Institute Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and Disorders China International Science and Technology Cooperation Base of Child Development and Critical Disorders Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders Children's Hospital of Chongqing Medical University Chongqing China.ORCID https://orcid.org/0000-0002-3411-7923
China International Science and Technology Cooperation · CNVancouver Coastal Health · CAChina Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The imbalance between neuronal excitation and inhibition (E/I) in neural circuit has been considered to be at the root of numerous brain disorders. We recently reported a novel feedback crosstalk between the excitatory neurotransmitter glutamate and inhibitory γ-aminobutyric acid type A receptor (GABA

Indexed as

epilepsyexcitation‐inhibition balanceGABAA receptorsynaptic transmission

Identifiers

PMID37101797
PMCPMC10123808
OpenAlexW4366826481

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.