Evidence map›Paper›PMID 37104777›Full record

ArticleBehavioral neuroscience2023

Divergent risky decision-making and impulsivity behaviors in Lewis rat substrains with low genetic difference.

Daniel B K Gabriel, Anna E Liley, Hunter T Franks, Grace L Minnes, Monika Tutaj, Melinda R Dwinell, Tristan V de Jong, Robert W Williams, Megan K Mulligan, Hao Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioral neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daniel B K GabrielDepartment of Psychology, University of Memphis.
Anna E LileyDepartment of Psychology, University of Memphis.ORCID 0000-0002-0059-9290
Hunter T FranksDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital.ORCID 0000-0002-8876-7155
Grace L MinnesDepartment of Psychology, University of Memphis.
Monika TutajDepartment of Physiology, Medical College of Wisconsin.
Melinda R DwinellDepartment of Physiology, Medical College of Wisconsin.
Tristan V de JongDepartment of Pharmacology, Addiction and Toxicology, University of Tennessee Health Science Center.
Robert W WilliamsDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center.
Megan K MulliganDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center.
Hao ChenDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center.ORCID 0000-0002-2680-6921
Nicholas W SimonDepartment of Psychology, University of Memphis.ORCID 0000-0001-9056-3509

Funding

TIM Project NIDA P30 CenterP30DA044223 · NIDA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI SEN, SAUNAK · 2017 to 2021
$3.9M
Identifying the neurophysiological basis of risky decision-makingR15DA046797 · NIDA · UNIVERSITY OF MEMPHIS · PI SIMON, NICHOLAS W · 2019 to 2019
$396k
The Role of Orbitofrontal Cortex in Risky Decision-MakingF31DA050458 · NIDA · UNIVERSITY OF MEMPHIS · PI GABRIEL, DANIEL · 2020 to 2021
$74k
NIDA NIH HHS F31 DA050458NIDA NIH HHS P30 DA044223NIDA NIH HHS R15 DA046797NIH HHS
6 · The paper itself

Abstract

Substance use disorder (SUD) is associated with a cluster of cognitive disturbances that engender vulnerability to ongoing drug seeking and relapse. Two of these endophenotypes-risky decision-making and impulsivity-are amplified in individuals with SUD and are augmented by repeated exposure to illicit drugs. Identifying genetic factors underlying variability in these behavioral patterns is critical for early identification, prevention, and treatment of SUD-vulnerable individuals. Here, we compared risky decision-making and different facets of impulsivity between two fully inbred substrains of Lewis rats-LEW/NCrl and LEW/NHsd. We performed whole genome sequencing of both substrains to identify almost all relevant variants. We observed substantial differences in risky decision-making and impulsive behaviors. Relative to LEW/NHsd, the LEW/NCrl substrain accepts higher risk options in a decision-making task and higher rates of premature responses in the

Indexed as

Behavior, AddictiveSubstance-Related DisordersAnimalsDecision MakingFemaleImpulsive BehaviorMaleRatsRats, Inbred LewReinforcement, PsychologyRisk-Taking

Identifiers

PMID37104777
PMCPMC10524952

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.