Evidence map›Paper›PMID 37107586›Full record

ArticleGenes2023

The Association of Calcium Signaling Pathway Gene Variants, Bone Mineral Density and Mild Cognitive Impairment in Elderly People.

Jiesong Zhang, Xueyan Wang, Haiping Duan, Chen Chen, Zhonghai Lu, Dongfeng Zhang, Suyun Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jiesong ZhangDepartment of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao 266012, China.
Xueyan WangDepartment of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao 266012, China.
Haiping DuanQingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, China.
Chen ChenDepartment of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao 266012, China.ORCID 0000-0002-1440-5012
Zhonghai LuDepartment of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao 266012, China.
Dongfeng ZhangDepartment of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao 266012, China.
Suyun LiDepartment of Epidemiology and Health Statistics, School of Public Health, Qingdao University, Qingdao 266012, China.
Qingdao University · CNQingdao Municipal Center for Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The association of calcium signaling pathway gene variants, bone mineral density (BMD) and mild cognitive impairment (MCI) is poorly understood so far. A total of 878 participants from Qingdao city were recruited in this study. According to the candidate gene selection method, 58 single nucleotide polymorphisms (SNPs) in eight calcium signaling genes were selected. The association between gene polymorphisms and MCI was revealed by using multiple genetic models. Polygenic risk scores (PRS) were used to summarize the effects of the whole gene. Logistic regression was used to analyze the association between each PRS and MCI. The multiplicative interaction term in the regression models was used to estimate the interaction effects between the PRS and BMD. We observed significant associations of rs6877893 (NR3C1), rs6448456 (CCKAR), and rs723672 (CACNA1C) polymorphisms with MCI. The PRSs of NR3C1 (OR = 4.012, 95% CI = 1.722-9.347,

Indexed as

Cognitive DysfunctionTRPM Cation ChannelsAgedBone DensityCalcium SignalingHumansPolymorphism, Single NucleotideRisk FactorsTRPM1 protein, humanTRPM Cation Channelsbone mineral densitycalcium signaling pathwayinteraction effectmild cognitive impairmentpolygenic risk scores

Identifiers

PMID37107586
PMCPMC10137633
OpenAlexW4361274823

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.