Evidence map›Paper›PMID 37108137›Full record

ArticleInternational journal of molecular sciences2023

Carborane-Containing Hydroxamate MMP Ligands for the Treatment of Tumors Using Boron Neutron Capture Therapy (BNCT): Efficacy without Tumor Cell Entry.

Sebastian Flieger, Mao Takagaki, Natsuko Kondo, Marlon R Lutz, Yash Gupta, Hiroki Ueda, Yoshinori Sakurai, Graham Moran, Prakasha Kempaiah, Narayan Hosmane and 2 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Structure optimization and molecular dynamics studies of new tumor-selectiveJournal of enzyme inhibition and medicinal chemistry · 2024
    Article
  4. Selective Functionalization of CarbonylMolecules (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Sebastian FliegerDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL 60660, USA.ORCID 0000-0003-3042-0543
Mao TakagakiResearch Center for Nuclear Physics, Osaka University, 10-1 Mihoga-oka, Ibaraki-City 567-0047, Osaka, Japan.
Natsuko KondoParticle Radiation Oncology Research Center, Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2-1010 Asashiro-Nishi, Kumatori, Sennan-gun 590-0494, Osaka, Japan.ORCID 0000-0003-0895-4581
Marlon R LutzDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL 60660, USA.
Yash GuptaDepartment of Medicine, Infectious Diseases, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0003-3002-1315
Hiroki UedaParticle Radiation Oncology Research Center, Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2-1010 Asashiro-Nishi, Kumatori, Sennan-gun 590-0494, Osaka, Japan.
Yoshinori SakuraiParticle Radiation Oncology Research Center, Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2-1010 Asashiro-Nishi, Kumatori, Sennan-gun 590-0494, Osaka, Japan.
Graham MoranDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL 60660, USA.ORCID 0000-0002-6807-1302
Prakasha KempaiahDepartment of Medicine, Infectious Diseases, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-2901-0339
Narayan HosmaneDepartment of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL 60115, USA.ORCID 0000-0002-6421-7546
Minoru SuzukiParticle Radiation Oncology Research Center, Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2-1010 Asashiro-Nishi, Kumatori, Sennan-gun 590-0494, Osaka, Japan.
Daniel P BeckerDepartment of Chemistry and Biochemistry, Loyola University Chicago, Chicago, IL 60660, USA.ORCID 0000-0001-9392-0460
Kyoto University · JPLoyola University Chicago · USMayo Clinic in Florida · USNorthern Illinois University · USThe University of Osaka · JP

Funding

Loyola University Chicago IPRS#929
6 · The paper itself

Abstract

New carborane-bearing hydroxamate matrix metalloproteinase (MMP) ligands have been synthesized for boron neutron capture therapy (BNCT) with nanomolar potency against MMP-2, -9 and -13. New analogs are based on MMP inhibitor CGS-23023A, and two previously reported MMP ligands

Indexed as

Boron Neutron Capture TherapyGliomaBoron CompoundsHumansLigandsVirus InternalizationBoron CompoundsLigandsantitumorbinary radiation therapyBNCTboron delivery agentsboron neutron capture therapycancercarboranematrix metalloproteinaseMMP

Identifiers

PMID37108137
PMCPMC10139035
OpenAlexW4363675571

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.